Changes in lipid fluidity and composition of lamellar bodies in respiratory distress induced by oleic acid.

  1. CRISTINA CASALS 2
  2. LUZ HERRERA 2
  3. EUGENIO MIGUEL 2
  4. PEDRO GARCIA-BARRENO 1
  5. ANGEL M. MUNICIO 1
  1. 1 Hospital General Universitario Gregorio Marañón
    info

    Hospital General Universitario Gregorio Marañón

    Madrid, España

    ROR https://ror.org/0111es613

  2. 2 Universidad Complutense de Madrid
    info

    Universidad Complutense de Madrid

    Madrid, España

    ROR 02p0gd045

Revista:
Biochem Soc Trans

ISSN: 0300-5127,  1470-8752

Año de publicación: 1989

Páginas: 792-794

Tipo: Artículo

DOI: 10.1042/BST0170792 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Biochem Soc Trans

Resumen

It is generally accepted that the lamellar bodies are theintracellular storage sites of pulmonary surfactant. Lamellar bodies are characterized by a high phospholipid/proteinratio, their lipid composition being very similar to the corresponding patterns of extracellular surfactant (Possmayer,1984). Very recently, we showed that the molecular speciescomposition of phosphatidylcholine (PC) from lamellarbodies and surfactant is very similar and that lamellar bodiescontain more dipalmitoyl-PC and less 1-palmitoyl-2-oleoylPC than other type I1 pneumocyte membranes (Schlame etal., 1988). Concerning surfactant proteins, recent studieshave showed that the surfactant apoprotein SF'26-36 isassociated with the phospholipid lamellae and the peripheryof the lamellar body (Walker et al., 1986). However, immunocytochemical localization of SP5-18 proteins to type I1 cellsor other lung cells has not been reported.

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Financiadores

  • Comisión Asesora de Investigacion Científica y Técnica Spain
    • grant no. 0490-84

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