Association of changes in lysophosphatidylcholine metabolism and in microsomal membrane lipid composition to the pulmonary injury induced by oleic acid.

  1. Cristina Casals 12
  2. Luz Herrera 12
  3. Pedro García-Barreno 12
  4. Angel M.Municio 12
  1. 1 Universidad Complutense de Madrid
    info

    Universidad Complutense de Madrid

    Madrid, España

    ROR 02p0gd045

  2. 2 Hospital General Universitario Gregorio Marañón
    info

    Hospital General Universitario Gregorio Marañón

    Madrid, España

    ROR https://ror.org/0111es613

Revue:
Biochem Biophys Acta

ISSN: 0006-3002

Année de publication: 1990

Volumen: 1023

Número: 2

Pages: 290-293

Type: Article

DOI: 10.1016/0005-2736(90)90425-N GOOGLE SCHOLAR lock_openAccès ouvert editor

D'autres publications dans: Biochem Biophys Acta

Résumé

Alterations in the lipid composition of lung microsomal membranes occur in oleic acid-induced respiratory distress. The marked decrease in the phosphatidylcholine/lysophosphatidylcholine molar ratio could be related with an altered metabolism of lysophosphatidylcholine in these membranes. Results revealed that the activity of phospholipase A increased whereas that of acyl-CoA:lysophosphatidylcholine acyltransferase decreased. Microsomal lysophospholipase activity remained unchanged. On the other hand, the microsomal enzyme system involved in the de novo synthesis of diacylglycerol was impaired, and cholinephosphotransferase activity was lowered. These changes in the activity of some membrane-bound enzymes were not caused by changes in the membrane lipid fluidity since lipid structural order parameter () did not change and neither did the major factors on which the fluidity depends. The possible significance of microsomal lipid alterations in the pathogenesis of respiratory distress induced by oleic acid is discussed.

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This work was supported by the Grant PR84-0490 from the Comisión Asesora de Investigación Científica y Técnica.

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