Investigación original sobre la epiteliosis mamaria canina. Una amenaza de interés en la clínica oncológica de pequeños animales

  1. EDGAR GUILLERMO VALDIVIA LARA 1
  2. ÁNGELA ALONSO DÍEZ 1
  3. DANIEL ALONSO MIGUEL 1
  4. MARÍA SUÁREZ REDONDO 1
  5. PALOMA MARTA GARCÍA FERNÁNDEZ 1
  6. GUSTAVO ORTIZ DÍEZ 1
  7. DOLORES PÉREZ ALENZA 1
  8. LAURA PEÑA FERNÁNDEZ 1
  1. 1 Universidad Complutense de Madrid
    info

    Universidad Complutense de Madrid

    Madrid, España

    ROR 02p0gd045

Journal:
Anales de la Real Academia de Ciencias Veterinarias

Year of publication: 2020

Volume: 28

Issue: 28

Pages: 13-42

Type: Article

DIALNET GOOGLE SCHOLAR lock_openOpen access editor

Abstract

Canine mammary epitheliosis is considered a type of dysplasia that could progress into carcinoma. The aim was to evaluate the fre-quency and significance of epitheliosis in female dogs with mammary tumors. Female dogs with mammary tumors undergoing total mastec-tomy were included in this prospective study. Clinical, pathological and immunohistochemical (AE1 / AE3, CK14, p63, vimentin, calponin, HER-2, ER and RP) studies were perfor-med. Epidemiological, clinical, and pathological variables were statisti-cally analyzed. In total, 66 female dogs with unilateral (n=50) or bilateral (n=16) mastectomy and 82 complete mammary chains with 102 malig-nant mammary tumors were included. Epitheliosis was diagnosed in 38/66 patients (57.6%), especially in the elderly dogs (p=0.02). Epithe-liosis appeared co-located with the mammary tumor (15.8%) or in the next (5.3%), distant (15.8%) and in the next and distant mammary glands (63.2%). Epitheliosis affected both mammary chains in 43.8% of the ani-mals with bilateral mastectomy. The number and the extension of epithe-liosis was associated to the presence of malignant tumors (p=0.031) and lymph node metastases (p=0.003). Dogs with malignant tumors fre-quently had epitheliosis in a different mammary gland (p=0.008). Epitheliosis showed epithelial basal immunophenotype (AE1/AE3+, CK14+, p63-, vim-, calponin-), triple negative (HER-2-, RE-, PR-) which indicates a poor prognosis. Epitheliosis is a multifocal lesion, without macroscopic changes, which can have a wide extension through the mammary chain of female dogs with malignancy. It should be consi-dered in the surgical approach, as it may be responsible for the develop-ment of new malignant mammary tumors in non-operated mammary glands.

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