Identificación de un perfil molecular predictor de albuminuria en pacientes hipertensos con supresión crónica del sistema renina-angiotensina

Abstract

Moderately elevated albuminuria or microalbuminuria is a pathological condition defined as the abnormally high presence of albumin in urine; above 30 mg/g albumin/creatinine ratio (ACR). It is considered a marker of cardiovascular risk and renal damage. However, by the time it is detected in the urine, organ damage has already occurred. Clinical evidence reveals that a continuous association between albuminuria and cardio-renal risk exists even below established microalbuminuria ranges. However, normoalbuminuric subjects are considered at no risk in clinical practice even though a non-negligible percentage of them develops microalbuminuria in the medium to long term. If cardio-renal risk determination is only based on ACR >30 mg/g, a significant percentage of the population may be falling outside the scope of early therapeutic management that would avoid progression to a pathological condition...