Respuestas de las células ganglionares de la retina a la lesión y su prevención

  1. Vidal Villegas, Beatriz
Supervised by:
  1. Julián García Feijoo Director
  2. Manuel Anton Vidal Sanz Director
  3. José M. Martínez de la Casa Director

Defence university: Universidad Complutense de Madrid

Fecha de defensa: 20 December 2021

Committee:
  1. José M. Ramírez Sebastian Chair
  2. José Manuel Benítez del Castillo Sánchez Secretary
  3. María Dolores Pinazo Durán Committee member
  4. Carlo Nucci Committee member
  5. Carlos Belmonte Martínez Committee member
Department:
  1. Inmunología, Oftalmología y ORL

Type: Thesis

Teseo: 157742 DIALNET lock_openDocta Complutense editor

Abstract

The Retinal Ganglion Cells (RGCs) are the only retinal cells that send information to the brain and thus are essential for vision. It is a heterogeneous population since up to 46 different RGC types have been documented in mice. The different RGC types encode a particular aspect of visual information and send it to the brain, where theycontribute to image forming (IF) and non-image forming (NIF) visual functions. A type of RGC contains the visual pigment melanopsin and performs phototransductionand thus has been named intrinsically photosensitive RGC (ipRGC). Six types of ipRGCs have been described in mice that perform the NIF functions of the visual system. Recent studies have documented that the different RGC types respond differently to different types of injury and to neuroprotection...