Miocarditis aguda como manifestación de granulomatosis eosinofílica

  1. Calderón-Flores, Miguel 1
  2. Morán-Fernández, Laura 2
  3. García-Robles, José Antonio 3
  4. Enguita-Valls, Ana Belén 4
  5. Delgado-Jiménez, Juan Francisco 5
  1. 1 Servicio de Cardiología, Hospital Universitario 12 de Octubre, Madrid, España
  2. 2 Servicio de Cardiología, Hospital Universitario 12 de Octubre; Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares (CIBERCV), Madrid, España
  3. 3 Servicio de Medicina Interna, Hospital Universitario 12 de Octubre, Madrid, España
  4. 4 Servicio de Anatomía Patológica, Hospital Universitario 12 de Octubre, Madrid, España
  5. 5 Servicio de Cardiología, Hospital Universitario 12 de Octubre; Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares (CIBERCV); Facultad de Medicina de la Universidad Complutense de Madrid, Madrid, España
Show affiliations +
Journal:
Revista Española de Casos Clínicos en Medicina Interna (RECCMI)

ISSN: 2530-0792

Year of publication: 2022

Volume: 7

Issue: 1

Pages: 6-8

Type: Article

DOI: 10.32818/RECCMI.A7N1A3 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Revista Española de Casos Clínicos en Medicina Interna (RECCMI)

Abstract

We present the case of a young male traveller in Southeast Asia who consulted for chest pain, and was initially managed as an acute coronary syndrome. Once coronary artery disease was ruled out and hypereosinophilia was observed, we carried out a broad differential diagnosis of its possible causes. Complementary tests confirmed eosinophilic myocarditis with ventricular dysfunction. Further clinical history and tests led to a diagnosis of eosinophilic granulomatosis with polyangiitis. Following the introduction of drugs for heart failure, as well as corticosteroids and mepolizumab, the patient improved clinically, and the ejection fraction was completely recovered.

Bibliographic References

  • Valent P, Klion A, Horny H, Roufosse F, Gotlib J, Weller P et al. Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes. J Allergy Clin Immunol. 2012; 130(3): 607-612.e9. doi: https://doi.org/10.1016/j.jaci.2012.02.019.
  • Tefferi A. Blood Eosinophilia: A New Paradigm in Disease Classification, Diagnosis, and Treatment. Mayo Clin Proc. 2005; 80(1): 75-83. doi: https://doi.org/10.1016/S0025-6196(11)62962-5.
  • Jakes R, Kwon N, Nordstrom B, Goulding R, Fahrbach K, Tarpey J et al. Burden of illness associated with eosinophilic granulomatosis with polyangiitis: a systematic literature review and meta-analysis. Clin Rheumatol. 2021; 40(12): 4829-4836. doi: https://doi.org/10.1007/s10067-021-05783-8.
  • Al Umairi R, Al Manei K, Al Lawati F, Al Mahrouqi Y, Al Balushi F. Cardiac Involvement in Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Disease). Sultan Qaboos Univ Med J [SQUMJ]. 2021; 21(4): 644-647. doi: https://doi.org/10.18295/squmj.4.2021.038.
  • Blumetti L, De Perna M, Reinehr M, Pedrazzini G. Eosinophilic perimyocarditis associated with eosinophilic granulomatosis with polyangiitis: a case report. Eur Heart J Case Rep. 2021; 5(10): ytab399. doi: https://doi.org/10.1093/ehjcr/ytab399.
  • Uzzo M, Regola F, Trezzi B, Toniati P, Franceschini F, Sinico R. Novel Targets for Drug Use in Eosinophilic Granulomatosis With Polyangiitis. Front Med (Lausanne). 2021 Nov 2; 8: 754434. doi: https://doi.org/10.3389/fmed.2021.754434.
Data source: Dialnet