Efecto del ciclo ovárico sobre la regulación diferencial del infiltrado de neutrófilos en el tracto reproductor femenino inferior

Abstract

Vaginal immune system must reconcile the presence of symbiont microorganisms with the presence of spermatozoa and to prevent colonization by sexually transmitted pathogens. We know about thirty pathogens (bacteria, viruses, and parasites) transmitted by sexual contact. Eight of these pathogens are highly prevalent in the population: four are curable (Treponema pallidum, Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis) and four are currently incurable viral infections (HBV, HSV, HIV and HPV). According to the World Health Organization, every day, more than 1 million people worldwide contract sexually transmitted infections. Those infections are increasing every year with serious health consequences, health care costs and loss of fertility. Consequently, current efforts to understand STIs and their interaction with the immune system are not sufficient and more efforts are needed to seek imaginative solutions to this problem. Therefore, in this work we addressed the study of the mechanisms of vaginal and cervical mucosal regulation for reproduction to occur and prevent pathogen attack...