Immune Function, Oxidative, and Inflammatory Markers in Centenarians as Potential Predictors of Survival and Indicators of Recovery After Hospital Admission

  1. Martínez De Toda, Irene 23
  2. Vida, Carmen 23
  3. García-Salmones, Marta 1
  4. Alonso-Fernández, Patricia 1
  5. De La Fuente, Mónica 23
  1. 1 Servicio de Geriatría, Hospital Clínico San Carlos, Madrid, Spain
  2. 2 Department of Genetics, Physiology and Microbiology (Unit of Animal Physiology), Faculty of Biology, Complutense University, Madrid, Spain
  3. 3 Institute of Investigation Hospital 12 Octubre, Madrid, Spain
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Revista:
The Journals of Gerontology: Series A

ISSN: 1079-5006,  1758-535X

Año de publicación: 2019

Volumen: 75

Número: 10

Páginas: 1827-1833

Tipo: Artículo

DOI: 10.1093/GERONA/GLZ250 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: The Journals of Gerontology: Series A

Resumen

Several parameters of immune function, oxidative, and inflammatory stresses have been proposed as markers of health and predictors of longevity and mortality. However, it is unknown if any of these parameters can be used as predictors of survival in centenarians. Therefore, in a group of 27 centenarians, at the time of admission to the Clinical Hospital of Madrid, a series of immune function, antioxidant, oxidant, and inflammatory parameters were studied. Some centenarians survived and others did not, thus establishing two groups, “survivors” (n = 9) and “nonsurvivors” (n = 18). The results show that surviving centenarians display higher neutrophil chemotaxis and microbicidal capacity, natural killer activity, lymphoproliferation, glutathione reductase activity, and basal interleukin-10 release. Moreover, lower neutrophil and lymphocyte adherence, superoxide anion and malondialdehyde concentrations, and basal release of tumor necrosis factor α are also reported. The odds ratios for survival for these parameters were also calculated, with the highest odds ratios being the lymphoproliferative capacity and the ex vivo basal and stimulated release of interleukin-6 from mononuclear cells (odds ratio = 136.00). Therefore, these parameters have the potential to be used in the clinical setting as predictors of survival in centenarians. In the survivors group, the same parameters were also analyzed after 3 months. Because survivors showed an increase in neutrophil and lymphocyte chemotaxis capacity during the recovery period, reaching similar values to those observed in healthy centenarians, these parameters could be proposed as indicators of recovery.

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Información de financiación

Financiadores

  • FIS
    • PI15/01787
  • European Union and of UCM-Research Group

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