Relación entre la cuantificación de calcio coronario y la composición de la microbiota intestinal en sujetos sin enfermedad cardiovascular previaestudio piloto

  1. Ortega-Madueño, Isabel 1
  2. Modrego, Javier 2
  3. Gómez-Gordo, Rubén 2
  4. Ortega-Hernández, Adriana
  5. Pérez de Isla, Leopoldo 3
  6. Muñoz, Juan Carlos 4
  7. Nieto, M. Luisa 5
  8. Gómez-Garre, Dulcenombre
  1. 1 Servicio de Análisis Clínicos, Instituto de Medicina de Laboratorio, Hospital Clínico San Carlos-IdISSC, Madrid, España
  2. 2 Laboratorio de Biología Vascular y Microbiota, Hospital Clínico San Carlos-Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, España
  3. 3 Servicio de Cardiología, Hospital Clínico San Carlos-IdISSC, Madrid, España
  4. 4 Servicio de Cardiología, Hospital Universitario Río Hortega, Valladolid, España
  5. 5 Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, España
Erakutsi afiliazioak +
Aldizkaria:
Clínica e investigación en arteriosclerosis

ISSN: 0214-9168,  1578-1879

Argitalpen urtea: 2022

Alea: 34

Zenbakia: 4

Orrialdeak: 205-215

Mota: Artikulua

DOI: HTTPS://DOI.ORG/10.1016/J.ARTERI.2021.11.008 DIALNET GOOGLE SCHOLAR

Beste argitalpen batzuk: Clínica e investigación en arteriosclerosis

Laburpena

Aim To investigate the relationship between gut microbiota composition and the presence of coronary atherosclerosis assessed by coronary artery calcium (CAC) quantification in individuals without previous cardiovascular disease (CVD). Methods We included 20 patients over 18 years of age with no history of CVD who underwent multiple detector-computed tomography. From each patient, a stool sample was obtained to characterize gut microbiota composition by sequencing bacterial 16S ribosomal RNA gene. In addition, circulating levels of TNF-α and IL-1β, as well as trimethylamine N-oxide (TMAO) were determined in plasma samples by automated ELISA and capillary gas chromatography-mass spectrometry, respectively. Results The mean age of patients was 63.5 years and 60% were women. Half of patients had CAC >100 (Agatston score), and were characterized by a higher abundance of the phylum Proteobacteria, mainly of bacteria belonging to the families Enterobacteriaceae and than patients with a CAC ≤ 100. Moreover, bacterial genera identified as biomarkers, such as Enterobacter, Escherichia/Shigella y Klebsiella, were positively associated with inflammation levels and with TMAO production. Conclusion Our data shows a gut microbiota profile associated with the presence of coronary calcium in patients without previous CVD. Although there are no strategies to decrease the amount of coronary calcium, gut microbiota is highly malleable by several factors. The possibility of preventing and even intervening CVD progression through strategies targeted gut microbiota is a very attractive idea that deserves further studies.

Datuen iturria: Dialnet