Valoración forense de la intoxicación por mefedronamodelo para el análisis de la violencia basado en una revisión sistemática
- Ricardo Paniagua Izquierdo
- Víctor Dujo López 1
-
1
Universidad Complutense de Madrid
info
ISSN: 1576-9941
Año de publicación: 2019
Volumen: 19
Número: 1
Páginas: 127-149
Tipo: Artículo
Otras publicaciones en: Psicopatología Clínica Legal y Forense
Resumen
Mephedrone (4-methylmethcathinone) is a designer drug with psychostimulant and psychotomimetic effects that can generate psychotic alterations where the risk of aggression is increased. As it is not a detectable compound in conventional toxicological tests, it makes the diagnosis of intoxication difficult. Then, this article aims to understand the bases and etiopathogenesis of aggressive behavior under intoxication by mephedrone or analogous substances. For this purpose, a systematic review has been carried out in five databases that have generated a body of 38 articles. Using a cluster analysis of the results, is proposed a model that contemplates three phases in intoxication and acute withdrawal. Secondly, a continuum in the syndromic expression of intoxication with respect to pathognomonic features of the agitated delirium is observed. This makes possible a holistic perspective of the effects of mephedrone from its slightest manifestation to the most severe. The temporal sequencing can facilitate an assessment in terms of criminal capacity, in addition to determining the main risk factors useful in forensic practice.
Referencias bibliográficas
- Alcázar-Córcoles, J. A. y Bezos-Saldaña, L. (2011). Cocaetileno y violencia: influencia de la Interacción cocaínaalcohol en la conducta antisocial. Anuario de Psicología Jurídica, 21, 49-55.
- American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders, fifth edition. Arlington, VA.
- Andreu, J. M., Ramírez, J. M. y Raine, A. (2006). Un modelo dicotómico de la agresión: valoración mediante dos auto-informes(CAMA y RPQ). Revista de Psicopatología Clínica, Legal y Forense, 6, 25-42.
- Aromatario, M., Bottoni, E., Santoni, M. y Ciacella, C. (2012). New “lethal highs”: a case of a deadly cocktail of GHB and mephedrone. Forensic Science International, 223, 38-41.
- Barrio, P., Gaskell, M., Goti, J., Vilardell, S. y Fàbregas, J. M. (2016). Persistent psychotic symptoms after longterm heavy use of mephedrone: a two-case series. Adicciones, 28(3), 154-157.
- Baumann, M. H., Partilla, J. S., Lehner, K. R., Thorndike, E. B., Hoffman, A. F., Holy, M., Rothman, R. B., Goldberg, S. R., Lupica, C. R., Sitte, H. H., Brandt, S. D., Tella, S. R., Cozzi, N. V., Schindler, C. W. (2013). Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive “bath salts” products. Neuropsychopharmacology, 38, 552-562.
- Bennett, K. H., Hare, H. M., Waller, R. M., Alderson, H. L. y Lawrie, S. (2017). Characteristics of NPS use in patients admitted to acute psychiatric services in Southeast Scotland: a retrospective cross-sectional analysis following public health interventions. BMJ Open, 7: e015716.
- Benzer, T. I., Nejad, S. H. y Flood, J. G. (2013). Case 40-2013: a 36-year-old man with Agitation and Paranoia. New England Journal of Medicine, 369(26), 2536-2545.
- Boletín Oficial del Estado N.º 34 de 9 de febrero de 2011, páginas 13595-13596. Orden SPI/201/2011, 3 de febrero, por la que se incluye la sustancia 4-metilmetcatinona (mefedrona) en el Anexo I del Real Decreto 2829/1977 de 6 de octubre. https://www.boe.es/boe/dias/2011/02/09/pdfs/BOE-A-2011-2490.pdf
- Brennan, R. y Van Hout, M. C. (2012). Miaow Miaow: a review of the new psychoactive drug mephedrone. Drugs and Alcohol today, 12(4), 241-253.
- Brookman, F., Bennett, T. H. y Hills, R. (2016). The pleasures and pains of mephedrone use: perceptions of users and practitioners. Drugs: Education, Prevention and Policy.
- Brookman, F. y Bennet, T. H. (2017). Fighting like M-Cats and dogs: users’ perceptions of the link between mephedrone use and violence. European Journal of Criminology, 15(2)151-171.
- Calinski, D. M., Kisor, D. F. y Sprague, J. E. (2019). A review of the influence of functional group modifications to the core scaffold of synthetic cathinones on drug pharmacokinetics. Psychopharmacology, 236, 881– 890.
- Capriola, M. (2013). Synthetic cathinone abuse. Clinical Pharmacology: Advances and Applications, 5, 109-115.
- Carrasco, J. J. y Maza, J. M. (2005). Manual de psiquiatría legal y forense. Madrid: La Ley.
- Center for Disease Control and Prevention (2011). Emergency department visits after use of a drug sold as “bath salts”: Michigan, november 13, 2010-March 31, 2011. Morbidity and Mortality Weekly Report, 60(19), 624-627.
- Curto, J., Dolengevich, H., Soriano, R. y Belza, M. J. (2020). Documento técnico: abordaje de la salud mental del usuario con prácticas de Chemsex. Ministerio de Sanidad. Madrid: MSD.
- Diario Oficial de la Unión Europea L322 del 8.12.2010, p. 44/45. Decisión del Consejo (2010/759/UE), de 2 de diciembre de 2010, por la que se somete la 4-metilmetcatinona (mefedrona) a medidas de control.
- Dolengevich-Segal, H., Rodríguez-Salgado, B., Gómez-Arnau, J. y Sánchez-Mateos, D. (2016). Severe psychosis, drug dependence, and hepatitis C related to slamming mephedrone. Case Reports in Psychiatry, Article ID 8379562.
- Drugs Enforcement Administration U.S. Department of Justice. (2020). Drugs of abuse: a DEA resource guide/ 2020 edition.
- Dujo, V., Horcajo-Gil, P. J. y González-Trijueque, D. (2016). Informe pericial psicológico: drogadicción y responsabilidad penal. Psicopatología Clínica Legal y Forense, 16(1), 114-128.
- Elliott, S. y Evans, J. (2014). A 3-year review of new psychoactive substances in casework. Forensic Science International, 243, 55-60.
- Esbec Rodríguez, E. y Echeburúa Odriozola, E. (2014). La prueba pericial en la jurisdicción penal en los consumidores de drogas y drogodependientes: una valoración integral. Psicopatología Clínica, Legal y Forense, 14, 189-215.
- Esbec Rodríguez, E. y Echeburúa Odriozola, E. (2016). Abuso de Drogas y delincuencia: consideraciones para una valoración forense integral. Adicciones, 28(1), 48-56.
- Fantegrossi, W. E., Gannon, B. M., Zimmerman, S. M. y Rice, K. C. (2013). In vivo effects of abused “bath salt” constituent 3,4-methylenedioxypyrovalerone (MDPV) in mice: drug discrimination, thermoregulation and locomotor activity. Neuropsychopharmacology, 38, 563-573.
- de Felice, L. J., Glennon, R. A. y Negus, S. S. (2014). Synthetic Cathinones: chemical phylogeny, physiology and Neuropharmacology. Life Science, 97(1), 20–26.
- Freeman, T. P., Morgan, C. J. A., Vaughn-Jones, J., Hussain, N., Karimi, K. y Curran, H. V. (2012). Cognitive and subjective effects of mephedrone and factors influencing use of a “new legal high.” Addiction, 107(4), 792-800.
- German, C. L., Fleckenstein, A. E. y Hanson, G. R. (2014). Bath salts and synthetic cathinones: an emerging designer drug phenomenon. Life Science, 27(1), 2-8.
- German, C. L., Hoonakker, A. H., Fleckenstein, A. E. y Hanson, G. R. (2014). Mephedrone alters basal ganglia and limbic neurotensin systems. Journal of Neurochemistry, 130(3), 402-407.
- Goldstein, P. J. (1985). The drugs/violence nexus: a tripartite conceptual framework. Journal of Drugs Issues, 39, 143-174.
- Gołembiowska, K., Jurczak, A., Kaminska, K., Noworyta-Sokołowska, K. y Górska, A. (2016). Effect of some psychoactive drugs used as “legal highs” on brain neurotransmitters. Neurotoxicity Research, 29, 394- 407.
- Gray, R., Bressington, D., Hughes, E. y Ivanecka, A. (2016). A systematic review of the effects of novel psychoactive substances “legal highs” on people with severe mental illness. Journal of Psychiatric and Mental Health Nursing, 22(5), 267-281.
- Green, A. R., King, M. V., Shortall, S. E. y Fone, K. C. F. (2014). The preclinical pharmacology of mephedrone; not just MDMA by another name. British journal of Pharmacology, 171, 2251-2268.
- Grela, A., Gautam, L. y Cole, M. D. (2018). A multifactorial critical appraisal of substances found in drug facilitated sexual assault cases. Forensic Science International, 292, 50-60.
- Hadlock, G. C., Webb, K. M., McFadden, L. M., Chu, P. W., Ellis, J. D., Allen, S. C., (…) Fleckenstein, A. E. (2011). 4-methylmetcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse. The Journal of Pharmacology and Experimental Therapeutics, 339(2), 530–536.
- Hollander den, B., Rozov, S., Linden, A. M., Uusi-Oukari, M., Ojanperä, I. y Korpi, E. R. (2013). Long-term cognitive and neurochemical effects of “bath salt” designer drugs methylone and mephedrone. Pharmacology, Biochemistry and Behavior, 103, 501-509.
- Hollander den, B., Mateusz, D., Ojanperä, I., Kankuri, E., Hyytiä, P. y Korpi, E. R. (2015). Manganese-enhanced magnetic resonance imaging reveals differential long-term neuroadaptation after methamphetamine and the substituted cathinone 4-methylmethcathinone (mephedrone). International Journal of Neuropsychopharmacology, 18(6), 1-9.
- Homman, L., Seglert, J. y Morgan, M. J. (2018). An observational study on the sub-acute effects of mephedrone on mood, cognition, sleep and physical problems in regular mephedrone users. Psychopharmacology, 235, 2609-2618.
- Imam, S. F., Patel, H., Mahmoud, M., Prakash, N. A., King, M. S. y Fremont, R. D. (2013).Bath saltsintoxication: a case series. Journal of Emergency Medicine, 45(3), 361-365.
- James, D., Adams, R. D., Spears, R., Cooper, G., Lupton, D. J., Thompson, J. P. y Thomas, S. H. L. (2010). Clinical characteristics of mephedrone toxicity reported to de UK National PoisonsInformation Service. Emergency Medical Journal, 28, 686-689.
- Jones, L., Reed. P., y Parrott, A. (2016). Mephedrone and 3,4-methylendioxymethanphetamine: comparative psychobiological effects as reported by recreational polydrug users. Journal of Psychopharmacology, 30, 1313-1320.
- Karila, L., Billieux, J., Benyamina, A., Lançon, C. y Cottencin, O. (2016). The effects and risks associated to mephedrone and methylone in humans: a review of the preliminary evidences. Brain Research Bulletin, 126, 61-67.
- Karlsson, L., Andersson, M., Kronstrand, R. y Kugelberg, F. C. (2014). Mephedrone, methylone and 3,4- methylendioxypyrovalerone (MDPV) produce conditioned place preference in Mice. Basic and Clinical Pharmacology and Toxicology, 115, 411-416.
- Liakoni, E., Gartwyl, F., Ricklin, M., Exadaktylos, A. K. y Krähenbühl, S. (2018). Psychoactive substances and violent offences: a retrospective analysis of presentations to an urban emergency department in Switzerland. PLoS ONE, 13(3), e0195234.
- Loeffler, G., Hurts, D., Penn, A. y Yung, K. (2012). Spice, bath salts, and the U.S. military: the emergence of synthetic cannabinoid receptor agonist and cathinones in the U.S. Armed Forces. Military Medicine, 177(9), 1041-1048.
- López-Rodríguez and A. B. y Viveros, M. P. (2019). Bath salts and polyconsumption: in search of drug-drug interactions. Psychopharmacology, 236, 1001-1014.
- Luethi, D., Kolaczyynska, K. E., Docci, L., Krähenbühl, S., Hoener, M. C. y Liechti, M. E. (2018). Pharmacological profile of mephedrone analogs and related new psychoactive substances. Neuropharmacology, 134, 4-12.
- Lusthof, K. J., Oosting, R., Maes, M., Verschraagen, M., Dijkhuizen, A. y Sprong, A. G. A. (2011). A case of extreme agitation and death after use of mephedrone in the Netherlands. Forensic Science International, 206, 93-95.
- Martín Ramírez, J. (2006). Bioquímica de la agresión. Psicopatología Clínica, Legal y Forense, 6, 43-66.
- Martínez-Clemente,J., Escubedo, E., Pubill, D. y Camarasa, J. (2012). Interaction of mephedrone with dopamine and serotonin targets in rats. European Neuropsychopharmacology, 22(3), 231-236.
- Martínez-Clemente, J., López-Arnau, R., Abad, S., Pubill, D., Escubedo, E. y Camarasa, J. (2014). Dose and timedependent selective neurotoxicity induced by mephedrone in mice. Plos one, 9(6), e99002.
- Martinotti, G., Lupi, M., Acciavatti, T., Cinosi, E., Santacroce, R., Signorelli, M. S. (…) di Giannantonio, M. (2014). Novel psychoactive substances in young adults with and without psychiatric comorbidities. BioMed Research International, ID 815424.
- Mash, D. C. (2016). Excited delirium and sudden death: a syndromal disorder at the extreme end of the neuropsychiatric continuum. Frontiers in Physiology, 7(435).
- Molins Pacual, S., Serrano, R., Ibarguchi, L. y Dolengevich Segal, H. (2019). Abordaje multidisciplinar del síndrome de abstinencia grave a ácido gamma-hidroxibutírico y 3-metilmetcatinona. Medicina Clínica Práctica, 2(1), 1-3.
- Murphy, C. M., Dulaney, A. R., Beuhler, M. C. y Kacinko, S. (2013). “Bath salts” and “plant food” products: the experience of one regional US Poison Center. Journal of Medical Toxicology, 9, 42-48.
- Observatorio Español de las Drogas y las Adicciones (2019). Informe 2019: alcohol, tabaco y drogas ilegales en España. Delegación del Gobierno para el plan nacional sobre Drogas.
- Odenwald, M., Neuner, F., Schauer, M., Elbert, T., Catani, C., Lingenfelder, B. (…) Rockstroh, B. (2005). Khat use as risk factor for psychotic disorders: a cross-sectional and case-control study in Somalia. BMC Medicine, 3(5).
- Oliver, C. F., Palamar, J. J., Salomone, A., Simmons, S. J., Philogene-Khalid, H. L. (…) Rawls, S. M. (2019). Synthetic cathinone adulteration of illegal drugs. Psychopharmacology, 236, 869-879.
- O’Neill, C. (2017). Behind closed doors: risks and recreational drug use in rural Northern Ireland. Journal of Rural Mental Health, 41(2), 97-109.
- Osuna-Carrillo, E. A. (2013). Imputabilidad y consumo de sustanciastóxicas: pericia psiquiátrico forense. Revista Española de Drogodependencias, 38(2), 109-115.
- Paillet-Lolier, M., Cesbron, A., Le Boisselier, R., Burgine, J. y Debruyne, D. (2014). Emerging drugs of abuse: current perspectives on substituted cathinones. Substance Abuse and Rehabilitation, 5, 37-52.
- Pantano, F., Tittarelli, R., Mannocchi, G., Pacifici, R., di Luca, A., Busardò, F. P. y Marinelli, E. (2017). Neurotoxicity induced by mephedrone: an up-to-date review. Current Neuropharmacology, 15, 738-749.
- Parrott, A. C. (2018). Mood fluctuation and psychobiological instability: the same core functions are disrupted by novel psychoactive substances and established recreational drugs. Brain Sciences, 8(3), 43.
- Penders, T. M., Gestring, R. E. y Vilensky, D. A. (2012). Excited delirium following use of synthetic cathinones (bath salts). General Hospital Psychiatry, 34, 647-650.
- Perestelo-Pérez, L. (2013). Standards on how to develop and reportsystematic reviews in Psychology and Health. International Journal of Clinical and Health Psychology, 13, 49-57.
- Grupo de Trabajo del Plan Nacional sobre el SIDA (2019). Informe sobre Chemsex. España: Dirección General de Salud Pública Calidad e Innovación.
- Real Decreto 2819/1977, de 6 de octubre por el que se regulan las sustancias y preparados medicinales psicotrópicos, así como la fiscalización e inspección de su fabricación, distribución, prescripción y dispensación. Ministerio de Sanidad y Seguridad Social «BOE» núm. 274, de 16 de noviembre de 1977 Referencia: BOE-A-1977-27160.
- Rech, M. A., Donahey, E., Capiello Dziedzic, J. M., Oh, L. y Greenhalgh, E. (2015). New drugs of abuse. Pharmacotherapy, 35(2), 189-197.
- Roberts, L., Ford, N., Vale, J. A. y Bradberry, S. (2017). 11 analytically confirmed cases of mexedrone use among polydrug users. Clinical Toxicology, 55(3), 181-186.
- Ross, E. A. y Goldberg, B. A. (2011). “Bath salts” intoxication. New England Journal of Medicine, 365(10), 967- 968.
- Ross, E. A., Reisfield, G. M., Watson, M. C., Chonister, C. W. y Goldberg, B. A. (2012). Psychoactive “bath salts” intoxication with methylenedioxypyrovalerone. The American Journal of Medicine, 125(9), 854- 858.
- Shea, B. J., Reeves, B. C., Wells, G., Thuku, M., Hamel, C., Moran, J. (…) Henry, D. A. (2017). AMSTAR-2: a critical appraisal tool for systematic review that include randomized or non-randomized studies of healthcare interventions, or both. Research methods and reporting. BMJ, 358.j4008.
- Schifano, F., Corkery, J. y Ghodse, A. H. (2012). Suspected and confirmed fatalities associated with mephedrone (4-methylmethcathinone, “meaw, meaw”) in the United Kingdom. Journal of Clinical Psychopharmacology, 32(5), 710-714.
- Simmons, S. J., Leyrer-Jackson, J. M., Oliver, C. F., Hicks, C., Muschamp, J. M., Rawls, S. M. y Olive, M. F. (2019). Dark classics in chemical neuroscience: cathinone-derived psychostimulants. ACS Chemical Neuroscience, 9(10), 2379-2394.
- Spiller, H. A., Ryan, M., Weston, R. y Jansen, J. (2011). Clinical experience with and analytical confirmation of “bath salts” and “legal highs” (synthetic cathinones) in the United States. Clinical Toxicology, 49, 499- 505.
- Suyama, J. A., Banks, M. L. y Negus, S. S. (2019). Effects of repeated treatment with methcathinone, mephedrone and fenfluramine on intracranial self-stimulation in rats. Psychopharmacology, 236(3), 1057-1066.
- Thornton, S. L. y Gerona, R. R. (2012). Psychosis from a bath salt product containing flephedrone and MDPV with serum, urine and product quantification. Journal of Medical Toxicology, 8, 310-313.
- United Nations Office on Drugs and Crime (2011). Guidelinesfor the forensic analysis of drugs facilitating sexual assault and other criminal acts. Viena: United Nations Office.
- Valente, M. J., Guedes de Pinho, P., Bastos, M. L., Carvalho, F. y Carvalho, M. (2014). Khat and synthetic cathinones: a review. Arch Toxicology, 88, 15-45.
- Vallersnes, O. M., Dines, A. M., Wood. D. M., Yates, C., Heyerdahl, F., Hovda, K. E. y Giraudon, I. (2016). Psychosis associated with acute recreational drug toxicity: a european case series. BMC Psychiatry, 16: 293.
- Van Hout, M. C. y Bingham, T. (2012). “A costly turn on”: patterns of use and perceived consequences of mephedrone based head shop products amongst irish injectors. International Journal of Drug Policy, 23, 188-197.
- World Health Organization (2014). Mephedrone: critical review report (Agenda item 4.12). Expert Committee on Drug Dependence.
- Zaro, I., Navazo, T., Vázquez, J., García, A. y Ibarguchi, L. (2016). Aproximación al Chemsex en España 2016. Imagina MÁS y Apoyo positivo. Ministerio de Sanidad, Servicios Sociales e Igualdad.
- Zawilska, J. B. y Wojcieszak, J. (2013). Designer cathinones: an emerging class of novel recreational drugs. Forensic Science International, 231, 42-53.