Estudio epidemiológico y caracterización genética del virus de la hepatitis e en explotaciones porcinas

  1. FERNÁNDEZ-BARREDO Y DEL AMO, M.SALCEDA
unter der Leitung von:
  1. María Teresa Pérez Gracia Doktorvater/Doktormutter
  2. Ángel García Muñoz Co-Doktorvater/Doktormutter

Universität der Verteidigung: Universidad CEU - Cardenal Herrera

Fecha de defensa: 28 von Mai von 2007

Gericht:
  1. José Manuel Sánchez-Vizcaíno Rodríguez Präsident
  2. María Teresa Gómez Muñoz Sekretärin
  3. Malcolm Banks Vocal
  4. Manuel Antonio Rodríguez Iglesias Vocal
  5. Maria Esperanza Gómez Lucía-Duato Vocal

Art: Dissertation

Teseo: 139231 DIALNET

Zusammenfassung

This study describes the distribution of Hepatitis E virus (HEV) in a naturally infected swine population and the genetic relatedness of HEV strains on swine farms in Spain. Of fecal and serum samples collected from 191 pigs and manure-ditch samples collected from 21 farms, HEV was detected in 19%, 12%, and 38%, respectively, for an overall prevalence rate of 25%. The maximum prevalence rates for feces and serum were in pigs 13 to 16 wk old. A high prevalence of the virus in feces (18%) was observed in sows. Gene sequencing was performed on 30 strains from feces, serum, and manure ditch: the nucleotide identities varied from 85% to 99% when compared with those of other strains of genotype 3 isolated from swine. This is the first study in Europe to show the variation in virus distribution by age in feces and serum in a naturally infected swine population.