Perfil psicológico prequirúrgico de las mujeres con riesgo aumentado de cáncer de mama

  1. Luque Suárez, Sofía
  2. Olivares Crespo, María Eugenia
  3. Olivera Pérez-Frade, Helena
  4. Brenes Sánchez, Juana María
  5. López Picado, Amanda
  6. de la Puente Yagüe, Miriam
  7. Ruiz Rodríguez, Jorge
  8. González Palomares, Blanca
  9. Herrera de la Muela, María
Revista:
Psicooncología: investigación y clínica biopsicosocial en oncología

ISSN: 1696-7240

Año de publicación: 2022

Volumen: 19

Número: 2

Páginas: 255-268

Tipo: Artículo

DOI: 10.5209/PSIC.84039 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Psicooncología: investigación y clínica biopsicosocial en oncología

Objetivos de desarrollo sostenible

Resumen

Aim: analyze depressive and anxiety symptomatology, body image and quality of life in a group of women with genetic vulnerability to breast cancer who were going to undergo a riskreducing mastectomy. Method:184 women participated in this study, all of whom had an increased risk of breast cancer, either because they were BRCA1/2 mutation carriers or because they had several affected relatives. The psychological instruments used were: Hospital Anxiety and Depression Scale, Body Image Scale, European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire Core 30 and BR23. Results: The results of this study showed that the participants presented clinical anxiety symptomatology and subclinical depressive symptomatology. However, all the sample were at normative levels in body image and quality of life. Participants with previous diagnosis of cancer showed, higher dissatisfaction with their body image, lower levels on the scales of physical, and cognitive and global functioning on quality of life, as well as higher fatigue, more general pain also in the breast and in the arm compared to women without diagnosis. Conclusions: BRCA1/2 non-mutation carriers showed more symptomatology in the breast and in the arm fatigue than BRCA1/2 mutation carriers. BRCA1/2 mutation carriers had more economic difficulties than non-carriers. It is highly recommended a psychological intervention before a risk-reducing surgery.

Referencias bibliográficas

  • 1. Kurian AW, Hare EE, Mills MA, Kingham KE, McPherson L, Whittemore AS, et al. Clinical evaluation of a multiple-gene sequencing panel for hereditary cancer risk assessment. J Clin Oncol 2014; 32: 2001-9. https://doi.org/10.1200/JCO.2013.53.6607.
  • 2. Singer, C, Tea, M, Pristauz, G, Hubalek M, Rappaport C, Riedl CC, et al. Clinical Practice Guideline for the prevention and early detection of breast and ovarian cancer in women from HBOC (hereditary breast and ovarian cancer) families. Wien Klin Wochenschr 2015;127: 981-6 https://doi.org/10.1007/s00508-015-0880-x
  • 3. Milne RL, Osorio A, Cajal TR, Vega A, Llort G, de la Hoya M, et al. The average cumulative risks of breast and ovarian cancer for carriers of mutations in BRCA1 and BRCA2 attending genetic counseling units in Spain. Clin Cancer Res 2008;14: 2861-9. https://doi.org/10.1158/1078-0432.CCR-07-4436.
  • 4. Graeser MK, Engel C, Rhiem K, Gadzicki D, Bick U, Kast K, et al. Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers. J Clin Oncol 2009;27:5887-92. https://doi.org/10.1200/JCO.2008.19.9430.
  • 5. Roy R, Chun J, Powell S. BRCA1 and BRCA2: different roles in a common pathway of genome protection. Nat Rev Cancer 2012;12, 68-78. https://doi.org/10.1038/nrc3181
  • 6. Clark AS, Domchek SM. Clinical management of hereditary breast cancer syndromes. J Mammary Gland Biol Neoplasia 2011; 16, 17–25. https://doi.org/10.1007/s10911-011- 9200-x
  • 7. Thorat MA, Balasubramanian R. Breast cancer prevention in high-risk women. Best Pract Res Clin Obstet Gynaecol 2020; 65:18-31. http://dx.doi.org/10.1016/ j.bpobgyn.2019.11.006.
  • 8. Evans DG, Ingham SL, Baildam A, Ross GL, Lalloo F, Buchan I, et al. Contralateral mastectomy improves survival in women with BRCA1/2-associated breast cancer. Breast Cancer Res Treat 2013;140:135–42. http://dx.doi.org/10.1007/ s10549-013-2583-1.
  • 9. Underhill ML, Crotser CB. Seeking balance: decision support needs of women without cancer and a deleterious BRCA1 or BRCA2 mutation. J Genet Couns 2014; 23:350-62. https://doi.org/10.1007/s10897-013-9667-2.
  • 10. Jeffers L, Reid J, Fitzsimons D, Morrison PJ, Dempster M. Interventions to improve psychosocial well-being in female BRCA-mutation carriers following riskreducing surgery. Cochrane Database Syst Rev 2019;10:CD012894. https://doi. org/10.1002/14651858.CD012894.pub2.
  • 11. Metcalfe KA, Price MA, Mansfield C, Hallett DC, Lindeman GJ, Fairchild A, et al. Predictors of long-term cancer-related distress among female BRCA1 and BRCA2 mutation carriers without a cancer diagnosis: an international analysis. Br J Cancer 2020;123: 268-74. http://dx.doi.org/10.1038/s41416- 020-0861-3.
  • 12. Razdan SN, Patel V, Jewell S, Mccarthy CM. Quality of life among patients after bilateral prophylactic mastectomy: a systematic review of patient-reported outcomes. Qual Life Res 2016;25:1409-21. https://doi.org/10.1007/s11136-015-1181-6
  • 13. Ibáñez E, Caro I. La escala Hospitalaria de ansiedad y depresión. Su utilidad práctica en Psicología de la Salud. Boletín de Psicología. 1992;36: 43-69.
  • 14. Gómez-Campelo P, Bragado-Álvarez C, Hernández-Lloreda M, Sánchez-Bernardos M. The Spanish version of the Body Image Scale (S-BIS): psychometric properties in a sample of breast and gynaecological cancer patients. Support Care Cancer 2015;23:473–81. doi: 10.1007/s00520-014-2383-0
  • 15. Arrarás JI, Illarramendi JJ, Tejedor M, Vera R, Pruja E, Marcos M et al. Quality of life in Spanish breast cancer patients assessed with the EORTC questionnaires. Rev Oncología 2000; 3: 100-6. https://doi.org/10.1007/BF02711461
  • 16. Wagner JF, Lüdders D, Hoellen F, Rody A, Banz-Jansen C. Treatment anxiety in breast cancer patients. Arch Gynecol Obstet 2019;299:1365-71 https://doi.org/10.1007/s00404- 018-05038-z
  • 17. Bosch N, Junyent N, Gadea N, Brunet J, Ramon y Cajal T, Torres A, et al. What factors may influence psychological well being at three months and one year post BRCA genetic result disclosure? Breast 2012;21:755-60. https://doi.org/10.1016/j.breast.2012.02.004.
  • 18. Bai L, Arver B, Johansson H, Sandelin K, Wickman M, Brandberg Y. Body image problems in women with and without breast cancer 6–20 years after bilateral riskreducing surgery — a prospective follow-up study. Breast 2019; 44:120-7. http://dx.doi. org/10.1016/ j.breast.2019.01.013.
  • 19. Mosconi P, Colozza M, De Laurentiis M, De Placido S, Maltoni M. Survival, quality of life and breast cancer. Ann Oncol 2001;12 Suppl 3:S15-9. https://doi.org/10.1093/ annonc/12.suppl_3.s15. PMID: 11804378.
  • 20. Hurria, Somlo y Ahles. Renaming “Chemobrain”. Cancer Invest, 2007;25:6, 373- 377, DOI: 10.1080/07357900701506672
  • 21. Vannorsdall T.D. Cognitive changes related to cancer therapy. Med Clin North Am 2017;101:1115-34. https://doi.org/10.1016/j.mcna.2017.06.006.
  • 22. Paraskevi T. Quality of life outcomes in patients with breast cancer. Oncol Rev. 2012;6:7- 10. doi: https://doi.org/10.4081/oncol.2012.e2
  • 23. Murgic J, Soldic Z, Vrljic D, Samija I, Kirac I, Bolanca A, Kusic Z. Quality of life of Croatian breast cancer patients receiving adjuvant treatmentcomparison to long-term breast cancer survivors. Coll Antropol 2012;36:1335–41.
  • 24. Garrido Manzano M.V., López-Guillén García A., Vicente Pardo. J.M. Manual de Práctica Clínica 2015 SESPM Sociedad Española de Patología Mamaria. Capítulo 63 Valoración de la Capacidad Laboral en Pacientes con Cáncer de mama. 2015.
  • 25. Faller H, Schuler M, Richard M, Heckl U, Weis J, Küffner R. Effects of psychooncologic interventions on emotional distress and quality of life in adult patients with cancer: systematic review and meta-analysis. J Clin Oncol 2013; 31: 782-93. https://doi. org/10.1200/JCO.2011.40.8922
  • 26. Kołodziejczy A, , Pawłowski T. Negative body image in breast cancer patients. Adv Clin Exp Med 2019;28:1137-42. https://doi.org/10.17219/acem/103626.
  • 27. Boughey JC, Hoskin TL, Hartmann LC, Johnson JL, Jacobson SR, Degnim AC, et al. Impact of reconstruction and reoperation on long-term patient-reported satisfaction after contralateral prophylactic mastectomy. Ann Surg Oncol 2015;22:401-8. https://doi. org/10.1245/s10434-014-4053-3.
  • 28. Metcalfe KA, Eisen A, Wright F, Poll A, Candib A, McCready D, et al. Impact of rapid genetic testing for BRCA1 and BRCA2 at time of breast cancer diagnosis on psychosocial functioning. Breast Cancer Res Treat 2022;191:631-41. https://doi.org/10.1007/s10549- 021-06457-4.
  • 29. Unukovych D, Wickman M, Sandelin K, Arver B, Johansson H, Brandberg Y. Associations between reoperations and psychological factors after contralateral risk-reducing mastectomy: a two-year follow-up study. Int J Breast Cancer 2016; 20164604852. http:// dx.doi.org/10.1155/2016/ 4604852.
Fuente de los datos: Dialnet