El gen del receptor cannabinoide tipo 2 se asocia con la comorbilidad entre esquizofrenia y dependencia de cannabis y el gen de la enzima amidohidrolasa de ácidos grasos se asocia con la dependencia de cannabis en población española

  1. Francisco Arias Horcajadas 1
  2. José Ramón Dávila Piriz 2
  3. Alba Parra González 1
  4. Sergio Sánchez Romero 3
  5. Eva Sánchez-Morla 1
  6. Israel Ampuero Sánchez 4
  7. José Antonio Ramos Atance 5
  1. 1 Hospital Doce de Octubre. Madrid.
  2. 2 Instituto de Enseñanza Secundaria (IES) Alfonso X El Sabio (Toledo).
  3. 3 Hospital Universitario Fundación de Alcorcón. Madrid
  4. 4 Colegio Camino Real. Torrejón de Ardoz. Madrid.
  5. 5 Universidad Complutense de Madrid
    info

    Universidad Complutense de Madrid

    Madrid, España

    ROR 02p0gd045

Revista:
Adicciones: Revista de socidrogalcohol

ISSN: 0214-4840

Año de publicación: 2023

Volumen: 35

Número: 1

Páginas: 33-45

Tipo: Artículo

Otras publicaciones en: Adicciones: Revista de socidrogalcohol

Resumen

El sistema cannabinoide se ha asociado con varios trastornos psiquiátricos como la esquizofrenia y las adicciones. Diversos estudios han observado que algunos polimorfismos del receptor cannabinoide tipo 2 (CNR2), del receptor cannabinoide tipo 1 (CNR1) y del gen de la enzima amido hidrolasa de ácidos grasos (FAAH) pueden ser factores de riesgo de estos trastornos. Hemos analizado diversos polimorfismos del sistema cannabinoide en pacientes diagnosticados de esquizofrenia sin trastorno por uso de sustancias (n = 379), esquizofrenia con trastorno por uso de cannabis (n = 124), dependientes de cannabis sin psicosis asociada (n = 71) y un grupo de control (316) procedentes de diversos hospitales y centros de asistencia sanitaria españoles. Hemos encontrado una asociación entre los polimorfismos rs35761398 y rs12744386 del CNR2 con la presencia de esquizofrenia y trastorno por uso de cannabis comórbido y una pérdida de heterocigosidad en el polimorfismo rs324420 del gen FAAH con la dependencia de cannabis en población española. Los polimorfismos rs35761398 y rs12744386 en CNR2 son factores de riesgo para esquizofrenia en sujetos dependientes de cannabis. La pérdida de heterocigosidad en el polimorfismo rs324420 en el gen FAAH es un factor de riesgo para la dependencia de cannabis.

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