Biosynthesis and Biological Activity of Carbasugars
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Roscales García, Silvia
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Plumet Arjona, Joaquín
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1
Universidad Complutense de Madrid
info
ISSN: 1687-9341, 1687-935X
Ano de publicación: 2016
Volume: 2016
Número: 1
Páxinas: 1-42
Tipo: Artigo
Outras publicacións en: International Journal of Carbohydrate Chemistry
Resumo
The first synthesis of carbasugars, compounds in which the ring oxygen of a monosaccharide had been replaced by a methylenemoiety, was described in 1966 by Professor G. E. McCasland’s group. Seven years later, the first true natural carbasugar (5a-carba-RD-galactopyranose) was isolated from a fermentation broth of Streptomyces sp. MA-4145. In the following decades, the chemistryand biology of carbasugars have been extensively studied. Most of these compounds show interesting biological properties,especially enzymatic inhibitory activities, and, in consequence, an important number of analogues have also been prepared inthe search for improved biological activities. The aim of this review is to give coverage on the progress made in two importantaspects of these compounds: the elucidation of their biosynthesis and the consideration of their biological properties, including theextensively studied carbapyranoses as well as the much less studied carbafuranoses.
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