Regulación de la expresión de los receptores VPAC1 y VPAC2 en linfocitos T colaboradores humanos y su implicación funcional

Abstract

Due to their pivotal role monitoring and coordinating the immune response, alterations or disruptions in the CD4 T cell compartment could lead to the development of inflammatory or autoimmune diseases. CD4 lymphocytes are actively involved in the onset and development of the pathological state and are in close relationship with all the molecules from the microenvironment, which can modulate and disrupt their function. Neuropeptides, such as VIP, are found among those molecular mediators. It has been shown in several works its potential as anti-inflammatory or homeostatic mediator in pathological conditions, as rheumatoid arthritis (RA). Thus, the work related to this PhD thesis tries to analyse the role of VIP/receptors axis on different activation and differentiation states of human CD4 T cells, as well as the first steps in the downstream signalling of VPAC receptors...