Scaffolds biohíbridos de fibroína de seda y ácido hialurónico para la neuroprotección y reparación de la retina y del nervio óptico

Abstract

Vision is the most important sense for human beings. 80% of the sensory information that we perceive from our surroundings enters through the eyes, allowing us to appreciate all the outside world beauty, communicate and acquire knowledge. The visual pathway is made up of a complex system of interconnected neurons, beginning with the retina in the eyeball, passing through the optic nerve up to the highest visual processing center, the visual cortex. All sensory information is preprocessed by the retina, triggering electrical pulses that travel through the visual pathway until they reach the cortex, where visual perception occurs. Given the importance of vision for humans, for several millennia great philosophers, doctors and researchers dedicated all their efforts to understanding the functioning of this complex system and seeking therapies to its pathologies.The retina is a light-sensitive structure essential for vision. Briefly, it is a layered structure, formed by a network of neurons, the photoreceptors, interneurons, and RGC. Phototransduction occurs at the photoreceptors, highly specialized and polarized cells that convert light into electrical signals...