Síntesis y evaluación de ligandos tau-selectivos basados en estructuras de oxindol como potenciales agentes de imagen PET para diagnóstico in vivo de la Enfermedad de Alzheimer y otras tauopatías

Supervised by:
  1. Francisco Sánchez Sancho Director
  2. Aurelio García Csákÿ Director

Defence university: Universidad Complutense de Madrid

Fecha de defensa: 29 March 2022

  1. Miguel Angel Pozo García Chair
  2. María Angeles Canales Mayordomo Secretary
  3. Carlos del Pozo Losada Committee member
  4. Laura Lagartera Ortiz Committee member
  5. Antonio Marcilla Díaz Committee member

Type: Thesis


Alzheimer ’s disease (AD) belongs to the pathology group named Taupathies. Currently, more than 24 million people suffer from Alzheimer disease and other dementias. This represents a serious health problem, especially if we take into account that the diagnosis of AD can only be confirmed by a postmortem histological analysis. So we need more effective and non-invasive techniques for early diagnosis.AD presents two biomarkers: tau protein and amyloid β peptide. Tau protein is the main microtubule-associated protein, responsible for axonal stabilization, which allows the proper neuronal transport. In its aberrant form, tau undergo a process of hyperphosphorilation that leads to an abnormal aggregation, forming Paired Helicoidal Filaments (PHFs) and Neurofibrillary Tangles (NFTs) in the intraneuronal medium. This process drives to the loss of the biological activity of tau and as a consequence, the cognitive decline. In addition, the other biomarker in Alzheimer's disease, the β-amyloid peptide aggregates as an extracellular deposit, forming senile plaques (SPs), which can trigger a local inflammatory response...