Modelos estadísticos para el metanálisis de estudios de exactitud diagnóstica.Aplicación a diferentes escenarios de variabilidad entre estudios

  1. PLANA FARRAS, MARIA NIEVES
Supervised by:
  1. Javier Zamora Moreno Director
  2. Teresa Pérez Pérez Director

Defence university: Universidad Complutense de Madrid

Fecha de defensa: 08 March 2022

Committee:
  1. María Jesús López Herrero Chair
  2. Antonio Murciano Cespedosa Secretary
  3. Rafael Perera Salazar Committee member
  4. Víctor Abraira Committee member
  5. Gerard Urrútia-Cuchí Committee member

Type: Thesis

Teseo: 745866 DIALNET lock_openDocta Complutense editor

Abstract

The methodology of systematic review (SR) and metanalysis is the most robust forpooling the available evidence on the accuracy of a diagnostic test and obtaining an overall estimate of its sensitivity and specificity. The analysis of the heterogeneity in Diagnostic Test Accuracy Reviews (DTA) is the goal of this thesis. The objectives are: i. to evaluate the methods used to quantify heterogeneity in Cochrane DTA reviews; ii. To propose alternative measures to quantify heterogeneity; iii.To develop a web application to summarise diagnostic test accuracy results; iv. To apply this methodology to different clinical scenarios and v. To develop a guide for critical appraisal of DTA reviews...