Compuestos multidiana derivados de inhibidores de la rho-quinasa (rock) con potencial actividad frente a enfermedades neurodegenerativas

Abstract

The new advances in therapeutics have increased life expectancy, and therefore the percentage of elder people, leading to an increase in age-related pathologies such as neurodegenerative disorders. Alzheimer’s disease, Parkinson disease and amyotrophic lateral sclerosis (ALS) are some examples of these disorders, which are particularly relevant in drug discovery due to the absence of effective treatments.These age-related disorders have multiple and complex etiologies, since several physiological processes are altered at the same time, leading to a complex network of disturbances. In this scenario, the classical “one drug-one target” approach to drug discovery is not suitable to achieve an efficient therapy. The new approach of multiple target-directed ligands, which proposes that one chemical entity might be able to interact with several targets in a synergistic fashion, seems more promising...