Nanosistemas multicomponente basados en silice mesoporosa para el tratamiento de la infección bacteriana y el cáncer
- Isabel Izquierdo Barba Director
- Montserrat Colilla Nieto Director
Defence university: Universidad Complutense de Madrid
Fecha de defensa: 30 March 2022
- María Vallet-Regí Chair
- Blanca González Ortiz Secretary
- Jaime Esteban Committee member
- María del Puerto Morales Herrero Committee member
- Alejandro Baeza García Committee member
Type: Thesis
Abstract
This PhD Thesis focuses on the design, development and biological evaluation of smart nanomaterials for the treatment of two complex diseases: bacterial infection and cancer, both with a great health and economic impact in today's society.Regarding bacterial infection, the rapid emergence of antibiotic resistance continues to outpace the development of new drugs, which means that conventional therapies are limited by the defense mechanisms of the bacteria themselves, which evolve as they adapt to the drugs. In addition, problems of access of antimicrobial agents to localized areas and poor accumulation in these areas are also a problem. Similar difficulties are encountered in cancer, where the most common treatments such as chemotherapy cause many toxicity problems in patients. This is mainly ascribed to the non-selective nature of the chemotherapeutic agent, which also produces resistance and serious side effects that may even lead to the suspension of the treatment. In both pathologies, nanotechnology has been claimed as a versatile tool to develop nanocarriers with the ability to selectively target drugs to specific sites...