Medida de parámetros de colisión de electrones y radicales aniónicos con moléculas.Aplicación al estudio de radiosensibilizadores moleculares

Abstract

Over the last decades, the study of collisions between ions and molecules has attracted the interest of the scientific community in different fields of science and technology. Especially, the study of molecular interactions through several collisional processes plays an important role in astrophysics, plasma physics and medicine. In the present work, we have focused our interest on interactions involving secondary electrons and O2 radicals, mainly because their importance in physico-chemical processes related to planetary phenomena and those associated with the biological damage induced by ionizing radiation in humans. When ionising radiation interacts with living tissues produce a large quantity of low-energy electrons (LEEs). Those LEEs interact immediately with the molecular environment, by generating several secondary species, such as ions or free radicals; among them reactive oxygenated species (ROSs). ROSs radicals trigger physical, chemical, and finally biological processes, which can lead to lethal damage in cells through induced molecular dissociations. Due to the relevance of these processes to develop radiation-matter interaction models, this study has been devoted to obtaining a collisional data base (interaction cross section data) in order to contribute to the inclusion of ROS and LEE effects into these models...