Enfermedades renales tubulointersticiales. Nefritis intersticial aguda

  1. Vega Cabrera, C. 1
  2. Rivas Becerra, B. 1
  3. García Fernández, E. 2
  4. Fernández Juárez, G. 1
  1. 1 Servicio de Nefrología, Hospital Universitario La Paz, Madrid, España
  2. 2 Servicio de Anatomía Patológica, Hospital Universitario La Paz, Madrid, España
Journal:
Medicine: Programa de Formación Médica Continuada Acreditado

ISSN: 0304-5412

Year of publication: 2023

Issue Title: Enfermedades nefrourinarias (III): Enfermedades renales tubulointersticiales: tubulopatías y enfermedad quística renal

Series: 13

Issue: 81

Pages: 4765-4773

Type: Article

DIALNET GOOGLE SCHOLAR

More publications in: Medicine: Programa de Formación Médica Continuada Acreditado

Abstract

Acute interstitial nephritis (AIN) is characterised by an inflammatory infiltrate, oedema and tubulitis in the renal interstitial, and it usually leads to acute deterioration of kidney function. AIN refers to the acute form of the disease which causes swift deterioration of kidney function, while the chronic forms have a longer course in which histology detects more fibrosis. The definitive diagnosis of both pathologies is therefore histological, as there are currently no non-invasive markers to confirm or exclude them. Although its exact incidence is very hard to determine, it varies from 5%-27%, progressively increasing in incidence mainly in the elderly, which may be due to their increasing exposure to drugs and other trigger mechanisms. The causes of AIN have undergone a drastic change, as now the most common aetiology consists of pharmacological agents (more than 75%).

Bibliographic References

  • Caravaca Fontán F, Fernández Juárez G, Praga M. Acute kidney injury in interstitial nephritis. Curr Opin Crit Care. 2019;25(6):558-64.
  • Praga M, González E. Acute interstitial nephritis. Kidney Int. 2010;77(11):956-6
  • Praga M, Sevillano A, Aunon P, González E. Changes in the aetiology, clinical presentation and management of acute interstitial nephritis, an increasingly common cause of acute kidney injury. Nephrol Dial Transplant. 2015;30(9):1472-9.
  • Fernández Juárez GM, Villacorta Pérez J, Caravaca Fontán F, Cases Corana C, Sánchez Alamo B, Tato Ribera AM. Nuevos retos en las nefritis tubulointersticiales inducidas por fármacos. Nefrología. 2019;39:339-42.
  • Perazella MA. Diagnosing drug-induced AIN in the hospitalized patient: a challenge for the clinician. Clin Nephrol. 2014;81:381-8.
  • Nast CC. Medication-Induced Interstitial Nephritis in the 21st Century. Adv Chronic Kidney Dis. 2017;24(2):72-9.
  • Perazella MA, Markowitz GS. Drug-induced acute interstitial nephritis. Nat Rev Nephrol. 2010;6(8):461-70.
  • Moledina DG, Perazella MA. PPIs and kidney disease: from AIN to CKD. J Nephrol. 2016;29(5):611-6.
  • Cortázar FB, Marrone KA, Troxell ML, Ralto KM, Hoenig MP, Brahmer JR. Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors. Kidney Int. 2016;90(3):638-47.
  • Seethapathy H, Herrmann S, Sise M. Immune checkpoint inhibitors and kidney toxicity: Advances in diagnosis and management. Kidney Med. 2021;3(6):1074-81.
  • Díaz Mancebo R, Costero Fernández O, Vega Cabrera C, Olea Tejero T, Yébenes L, Picazo ML. Dress syndrome and acute tubulointerstitial nephritis after treatment with vancomycin and beta-lactams. Case report and literature review. Nefrologia. 2012;32(5):685-7.
  • Rossert JA, Fischer EA. Acute interstitial nephritis. En: Floege J, Johnson RJ, Feehally J, eds. Comprenhensive clinical nephrology. 6ª ed. Germany: Elsevier; 2019. p. 729-37.
  • Tanaka K, Tanabe K, Nishii N. Sustained tubulointerstitial inflammation in kidney with severe leptospirosis. Ann Inter Med. 2017;56:1117-84.
  • Outinen T, Makela S, Clement J, Pakkala A. Community acquired severe acute kidney injury caused by hantavirus induced hemorrhagic fever with renal syndrome has a favorable outcomes. Nephron. 2015;130:182-90.
  • Rubin S, Orieux A, Prevel R, Garric A, Bats ML, Dabernat S. Characterization of acute kidney injury in critically ill patients with severe coronavirus disease 2019. Clin Kidney J. 2020;13:354-61.
  • Oliva Damaso N, Oliva Damaso E, Payan J. Acute and chronic tubulointerstitial nephritis of rheumatic causes. Rheum Dis Clin North Am. 2018;44(4):619-33.
  • Paroli MP, Cappiello D, Staccini D, Caccavale R, Paroli M. Tubulointerstitial nephritis and uveitis syndrome (TINU): A case series in a tertiary care uveitis setting. J Clin Med. 2022;11(17):4995.
  • Joss N, Morris S, Young B. Granulomatous interstitial nephritis. Clin J Am Soc Nephrol. 2007;2(2):222-30.
  • Mahévas M, Lescure FX, Boffa JJ, Delastour V, Belenfant X, Chapelon C. Renal sarcoidosis: clinical, laboratory, and histologic presentation and outcome in 47 patients. Medicine (Baltimore). 2009;88:98-106.
  • Brause M, Magnusson K, Degenhardt S, Helmchen U, Grabensee B. Renal involvement in sarcoidosis a report of 6 cases. Clin Nephrol. 2002;57:142-8.
  • Joss N, Morris S, Young B, Geddes C. Granulomatous interstitial nephritis. Clin J Am Soc Nephrol. 2007;2:222.
  • Mori Y, Kishimoto N, Yamagata H. Predominant tubulointerstitial nephritis in a patient with systemic lupus nephritis. Clin Exp Nephrol. 2005;9:79-84.
  • Broder A, Mowrey WB, Khan HN, Jovanovic B, Londono Jiménez A, Izmirly P. Tubulointerstitial damage predicts end stage renal disease in lupus nephritis with preserved to moderately impaired renal function: A retrospective cohort study. Semin Arthritis Rheum. 2018;47(4):545-51.
  • Morrondo C, Lema JM, Álvarez N, Atanes A, de Toro F. Aspectos actuales del síndrome de Sjögren: etiopatogenia, manifestaciones clínicas, diagnóstico y tratamiento. Semin Fund Esp Reumatol. 2010;11(2):70-6.
  • Maripuri S, Grande JP, Osborn TG, Fervenza FC, Matteson EL, Donadio JV. Renal involvement in primary sjögren’s syndrome: A clinicopathologic study. Clin J Am Soc Nephrol. 2009;4:1423-31.
  • Francois H, Mariette X. Renal involvement in primary Sjogren syndrome. Nat Rev Nephrol. 2016);12:82-93.
  • Matignon M, Cacoub P, Colombat M, Saadoun D, Brocheriou I, Mougenot B, et al. Clinical and morphologic spectrum of renal involvement in patients with mixed cryoglobulinemia without evidence of hepatitis C virus infection. Medicine. 2009;88:341-8.
  • Jennette JC, Falk RJ. The pathology of vasculitis involving the kidney. Am J Kidney Dis. 1994;24:130-41.
  • Sakai N, Wada T, Shimizu M, Segawa C. Tubulointerstitial nephritis with anti-neutrophil cytoplasmic antibody following indomethacin treatment. Nephrol Dial Transplant. 1999;14:2774.
  • He X, Wen Y, Hu R, Wu H, Ye W, Yue C. Interstitial nephritis without glomerulonephritis in ANCA-associated vasculitis: a case series and literature review. Clin Rheumatol. 2022;41(11):3551-63.
  • Saeki T, Kawano M, Nagasawa T, Ubara Y, Taniguchi Y, Yanagita M. Validation of the diagnostic criteria for IgG4-related kidney disease (IgG4-RKD) 2011, and proposal of a new 2020 version. Clin Exp Nephrol. 2021;25(2):99-109.
  • Baltar Martin J, García Monteavaro C. Afectación renal de las enfermedades relacionadas con IgG4. NefroPlus. 2015;7(1):1-10.
  • Raghavan R, Shawar S. Mechanisms of drug-induced interstitial nephritis. Adv Chronic Kidney Dis. 2017;24(2):64-71.
  • Nielson EG. Pathogenesis and therapy of interstitial nephritis. Kidney Int. 1989;35:1257-70.
  • Raghavan R, Eknoyan G. Acute interstitial nephritis—A reappraisal and update. Clin Nephrol. 2014;82:149-62.
  • Bomback AS, Markowitz GS. Increased prevalence of acute interstitial nephritis: more disease or simply more detection. Nephrol Dial Transplant. 2013;28(1):16-8.
  • Wu Y, Yang L, Su T, Wang C, Liu G, Li X. Pathological significance of a panel of urinary biomarkers in patients with drug-induced tubulointerstitial nephritis. Clin J Am Soc Nephrol. 2010;5(11):1954-9.
  • Moledina DG, Parikh CR. Differentiating acute interstitial nephritis from acute tubular injury: A challenge for clinicians. Nephron. 2019;212:1-6.
  • Moledina DG, Wilson FP, Pober JS, Perazella MA, Singh N, Luciano RL. Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis. 2019;4(10):e127456. doi: 10.1172/jci.insight.127456.
  • Muriithi AK, Nasr SH, Leung N. Utility of urine eosinophils in the diagnosis of acute interstitial nephritis. Clin J Am Soc Nephrol. 2013;8:1857-62.
  • Fogazzi GB, Ferrari B, Garigali G, Simonini P, Consonni D. Urinary sediment findings in acute interstitial nephritis. Am J Kidney Dis. 2012;60:330-2.
  • Perazella MA. Clinical approach to diagnosing acute and chronic tubulointerstitial disease. Adv Chronic Kidney Dis. 2017; 24(2):57-63.
  • Qualls D, Seethapathy H, Bates H, Tajmir S, Heidari P, Endres P. Positron emission tomography as an adjuvant diagnostic test in the evaluation of checkpoint inhibitor-associated acute interstitial nephritis. J Immunother Cancer. 2019;7(1):356.
  • Fernández Juárez G, Pérez JV, Caravaca Fontán F, Quintana L, Shabaka A, Rodríguez E. Duration of treatment with corticosteroids and recovery of kidney function in acute interstitial nephritis. Clin J Am Soc Nephrol. 2018;13(12):1851-8.
  • González E, Gutiérrez E, Galeano C, Chevia C, de Sequera P, Bernis C. Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis. Kidney Int. 2008;73. 940-6.
  • Preddie DC, Markowitz GS, Radhakrishnan J, Nickolas TL, D’Agati VD, Schwimmer JA. Mycophenolate mofetil for the treatment of interstitial nephritis. Clin J Am Soc Nephrol. 2006;1:718-22.
Data source: Dialnet