Caracterización del tipo de respuesta inmunitaria y procesos trombóticos en COVID-19

Abstract

COVID-19 is a pathology caused by SARS-CoV-2 infection that presents a wide spectrum of clinical manifestations, from an asymptomatic profile to patients who develop life-threatening complications such as massive bilateral pneumonia or severe thrombotic events. Patients with the most severe forms are distinguished from the rest by presenting alterations in the immune profile, including lymphopenia or neutrophilia. As it has been described in other infectious processes, the type of immune response generated to control the disease is determinant for its evolution. A potentially beneficial immune response is one that occurs early in the infection in an efficient and self-limited manner. However, if the response is slow and with limited efficacy (the microorganism and the symptoms persist over time), it could become deleterious...