Estudio de biomarcadores en sangre periférica en mujeres con fallo reproductivo recurrente

Resumo

Recurrent reproductive failure encompasses two well-differentiated entities: recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF). RPL is defined as the loss of two or more pregnancies before 24 weeks of gestational age, while for RIF, there is no international consensus on its definition, but the most accepted would be the non-achievement of pregnancy in women under 40 years of age, after having transferred at least four good quality embryos, in a minimum of 3 transfers (including both those made fresh and those of cryopreserved embryos). Both pathologies share some etiologies, such as anatomical, genetic, and endocrine causes, among others. Therefore, in many patients, its origin remains unknown and can reach up to 50% in patients with RPL. In recent years, the immune system has gained vital importance in explaining a high degree of patients who previously remained as of unknown cause. The role that NK cells play in these two pathologies, both in number and function, has been extensively studied in the last 20 years. Likewise, monocytes, also essential cells for the development of pregnancy, have become more important in recent years, although their study has focused on their role in other pathologies, mainly preeclampsia. Initially, it was thought that a pro-inflammatory state during pregnancy could be detrimental to its proper development...