Efectos indirectos de la infección por citomegalovirus en una cohorte de receptores de trasplante renal

Abstract

Cytomegalovirus (CMV) is a member of the Herpesviridae family. After primoinfection, CMV can remain in host cells and reactivate in certain situations of immunosuppression, with solid organ transplantation (SOT) as one of the most common scenarios. In these patients, CMV may cause a direct tissue injury in the form of symptomatic clinical disease. However, CMV infection in SOT recipients has been also associated with the development of immunomodulatory phenomena (the so-called "indirect effects") that result from the interaction of the virus with the host's immune system and the associated tissue inflammation. In kidney transplant (KT) recipients previously exposed to CMV there has been described an increased risk of post-transplant non-CMV infection, BK polyomavirus infection and associated nephropathy, and post-transplant atherosclerotic (PAE) and thrombotic (PTE) events...