Choroidal Thickness Is a Biomarker Associated With Response to Treatment in Ankylosing Spondylitis

  1. Steiner, Martina 12
  2. Esteban-Ortega, María del Mar 12
  3. Thuissard-Vasallo, Israel 2
  4. García-Lozano, Isabel 1
  5. García-González, Alejandro Javier 3
  6. Pérez-Blázquez, Eugenio 3
  7. Sambricio, Javier 1
  8. García-Aparicio, Ángel 3
  9. Casco-Silva, Bruno Francisco 4
  10. Sanz-Sanz, Jesús 4
  11. Valdés-Sanz, Nuria 5
  12. Fernández-Espartero, Cruz 6
  13. Díaz-Valle, Teresa 7
  14. Gurrea-Almela, María 7
  15. Fernández-Melón, Julia 8
  16. Gómez-Resa, María 9
  17. Pato-Cour, Esperanza 9
  18. Díaz-Valle, David 10
  19. Méndez-Fernández, Rosalía 10
  20. Navío, Teresa 11
  21. Moriche-Carretero, Manuel 12
  22. Muñoz-Fernández, Santiago 12
  1. 1 Hospital Infanta Sofia
    info

    Hospital Infanta Sofia

    Madrid, España

    ROR https://ror.org/05dfzd836

  2. 2 Universidad Europea de Madrid
    info

    Universidad Europea de Madrid

    Madrid, España

    ROR https://ror.org/04dp46240

  3. 3 Hospital Universitario 12 de Octubre
    info

    Hospital Universitario 12 de Octubre

    Madrid, España

    ROR https://ror.org/00qyh5r35

  4. 4 Hospital Virgen de la Salud
    info

    Hospital Virgen de la Salud

    Toledo, España

    ROR https://ror.org/0289cxp23

  5. 5 Ophthalmology Department, Hospital Universitario de Majadahonda
  6. 6 Rheumatology Department, Hospital Universitario de Majadahonda
  7. 7 Hospital de Móstoles
    info

    Hospital de Móstoles

    Móstoles, España

    ROR https://ror.org/04tqrbk66

  8. 8 Rheumatology Department, Hospital Universitario de Móstoles
  9. 9 Hospital Universitario Son Espases
    info

    Hospital Universitario Son Espases

    Palma, España

    ROR https://ror.org/05jmd4043

  10. 10 Hospital Clínico San Carlos de Madrid
    info

    Hospital Clínico San Carlos de Madrid

    Madrid, España

    ROR https://ror.org/04d0ybj29

  11. 11 Hospital Infanta Leonor
    info

    Hospital Infanta Leonor

    Madrid, España

    ROR https://ror.org/05nfzf209

Journal:
JCR: Journal of Clinical Rheumatology

ISSN: 1076-1608

Year of publication: 2020

Type: Article

DOI: 10.1097/RHU.0000000000001458 GOOGLE SCHOLAR lock_openOpen access editor

More publications in: JCR: Journal of Clinical Rheumatology

Metrics

Cited by

  • Dimensions Cited by: 2 (07-02-2024)

JCR (Journal Impact Factor)

  • Year 2020
  • Journal Impact Factor: 3.517
  • Journal Impact Factor without self cites: 3.483
  • Article influence score: 0.848
  • Best Quartile: Q3
  • Area: RHEUMATOLOGY Quartile: Q3 Rank in area: 20/34 (Ranking edition: SCIE)

SCImago Journal Rank

  • Year 2020
  • SJR Journal Impact: 0.615
  • Best Quartile: Q2
  • Area: Medicine (miscellaneous) Quartile: Q2 Rank in area: 1120/2574
  • Area: Rheumatology Quartile: Q3 Rank in area: 37/67

Scopus CiteScore

  • Year 2020
  • CiteScore of the Journal : 2.4
  • Area: Medicine (all) Percentile: 71

Journal Citation Indicator (JCI)

  • Year 2020
  • Journal Citation Indicator (JCI): 0.53
  • Best Quartile: Q3
  • Area: RHEUMATOLOGY Quartile: Q3 Rank in area: 29/48

Dimensions

(Data updated as of 07-02-2024)
  • Total citations: 2
  • Recent citations (2 years): 2
  • Field Citation Ratio (FCR): 0.76

Abstract

Objective Choroidal thickness (CT) has been evaluated as a marker of systemic inflammation in ankylosing spondylitis (AS). This study evaluates the CT of AS patients before and after 6 months of biological treatment.Methods This longitudinal multicenter study evaluated CT in 44 AS patients. The correlations between CT and C-reactive protein (CRP) with disease activity indices were calculated. The concordance between CT and CRP was determined. We assessed factors associated with response to treatment. Clinically important improvement was defined as a decrease in Ankylosing Spondylitis Disease Activity Score of 1.1 points or greater.Results Forty-four eyes in patients aged 18 to 65 years were included. Mean CT values were significantly higher at baseline than after 6 months of treatment (baseline: 355.28 ± 80.46 μm; 6 months: 341.26 ± 81.06 μm; p < 0.001). There was a 95% concordance between CT and CRP at baseline and 6 months. Clinically important improvement was associated with lower baseline CT and age as independent factors (odds ratios, 0.97 [95% confidence interval, 0.91–0.93; p = 0.009] and 0.81 [95% confidence interval, 0.7–0.95; p = 0.005]), with baseline CT of less than 374 μm (sensitivity 78%, specificity 78%, area under the curve 0.70, likelihood ratio 3.6).Conclusions Choroidal thickness decreased significantly after 6 months of biological treatment in all treatment groups. Choroidal thickness and CRP had a 95% concordance. A high CT was associated with a risk of biological treatment failure. Choroidal thickness can be considered a useful biomarker of inflammation and a factor associated with response to treatment in AS.