Origen, desarrollo y nuevos mecanismos de resistencia a azoles en Aspergillus fumigatus

Resumo

In recent years, the extensive and widespread use of antifungals has led to the emergence of resistant fungi, involving severe consequences for patients infected with these isolates whose therapeutic options are being reduced. Aspergillus fumigatus is the main filamentous fungi producing fungal infections in humans. Its primary route of infection is through the inhalation of airborne conidia that the fungi releases to the air.In immunocompetent individuals, the immune system is able to clean A. fumigatus conidia from the respiratory airway. However, in onco-haemathology patients, transplant patients or other immunosuppression situations, the conidia can germinate inside the lungs producing a wide range of clinical manifestations named aspergillosis. Aspergillosis diseases can range from minor diseases to the most severe form, which is the invasive aspergillosis, depending on the host immune status...