Detección de anticuerpos anti-SARS-CoV-2 en lágrimasinmunidad de la superficie ocular frente a COVID-19

  1. Noemí Güemes-Villahoz 1
  2. B. Burgos-Blasco 1
  3. P.L. Echevarria-Torres 2
  4. B. Vidal-Villegas 1
  5. A. Rodriguez de la Peña 3
  6. D. Diaz-Valle 1
  7. J.I. Fernández-Vigo 1
  8. S. Sánchez-Ramón 23
  9. J. Garcia-Feijoo 1
  1. 1 Universidad Complutense de Madrid
    info

    Universidad Complutense de Madrid

    Madrid, España

    ROR 02p0gd045

  2. 2 Instituto de Ciencia y Tecnología de Polímeros
    info

    Instituto de Ciencia y Tecnología de Polímeros

    Madrid, España

    ROR https://ror.org/00bzgd159

  3. 3 Hospital Clínico San Carlos de Madrid
    info

    Hospital Clínico San Carlos de Madrid

    Madrid, España

    ROR https://ror.org/04d0ybj29

Erakutsi afiliazioak +
Aldizkaria:
Archivos de la Sociedad Española de Oftalmologia

ISSN: 0365-6691

Argitalpen urtea: 2023

Alea: 98

Zenbakia: 7

Orrialdeak: 397-403

Mota: Artikulua

DOI: 10.1016/J.OFTAL.2023.03.013 DIALNET GOOGLE SCHOLAR

Beste argitalpen batzuk: Archivos de la Sociedad Española de Oftalmologia

Laburpena

Purpose To evaluate the presence of SARS-CoV-2 specific IgA and IgG antibodies in tears of unvaccinated and anti-COVID-19 vaccinated subjects with previous history of SARS-CoV-2 infection. To compare results in tears with those in saliva and serum and correlate with clinical data and vaccination regimens. Methods Cross-sectional study including subjects with a previous history of SARS-CoV-2 infection, both unvaccinated and vaccinated against COVID-19. Three samples were collected: tears, saliva and serum. IgA and IgG antibodies against S-1 protein of SARS-CoV-2 were analyzed with a semi-quantitative ELISA. Results Thirty subjects, mean age 36.4 ± 10, males 13/30 (43.3%) with history of mild SARS-CoV-2 infection were included. 13/30 (43.3%) subjects had received a 2-dose regimen and 13/30 (43.3%) a 3-dose regimen of anti-COVID-19 vaccine, 4/30 (13.3%) subjects were unvaccinated. All the participants with full anti-COVID-19 vaccination (2-or 3-doses) presented detectable anti-S1 specific IgA in all 3 biofluids, tears, saliva and serum. Among unvaccinated subjects, specific IgA was detected in 3/4 subjects in tears and saliva, whereas IgG was not detected. Considering IgA and IgG antibodies titers, no differences were observed between the 2- and 3-dose vaccination regimen. Conclusions SARS-CoV-2-specific IgA and IgG antibodies were detected in tears after mild COVID-19, highlighting the role of the ocular surface as a first line of defense against infection. Most naturally infected unvaccinated individuals exhibit long-term specific IgA in tears and saliva. Hybrid immunization (natural infection plus vaccination) appears to enhance mucosal and systemic IgG responses. However, no differences were observed between the 2- and 3-dose vaccination schedule.

Datuen iturria: Dialnet