Role of Glucan-Derived Polymers in the Pathogenic Fungus Candida albicans
- 1 Departamento de Microbiología y Parasitología, Universidad Complutense de Madrid, Madrid, Spain
ISSN: 2211-0593, 2211-0607
ISBN: 9783030129187, 9783030129194
Ano de publicación: 2019
Páxinas: 393-407
Tipo: Capítulo de libro
Resumo
The cell wall is one of the most important structures to every fungi. Candida albicans is the most important fungal pathogen leading to superficial but also invasive infections which are frequently life-threatening. The C. albicans cell wall is composed of different polysaccharides, mainly mannan, chitin, and glucan. Glucans (β-(1,3) and β-(1,6)) differ in abundance among the different cellular morphologies (yeast or hypha) of this fungus but are essential to maintain the morphology of the cells and to provide protection against external injuries and as an anchoring scaffold to other components of the wall. In C. albicans, glucan is normally hidden in the inner wall layer, but it may be exposed in response to different environmental conditions and/or drug treatments. Glucans may play a role in biofilm formation and, most importantly, modulate immune recognition by phagocytes via the Dectin-1 receptor, therefore influencing the outcome of colonization and infection of this important pathogen.
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