Revisión de la evidencia científica sobre el papel de compuestos bioactivos de alimentos como coadyuvantes a los tratamientos antineoplásicos de cáncer de mama

  1. Sergio Dahdouh Cabia 1
  2. Laura M. Bermejo López 1
  3. Bricia López Plaza 1
  4. Samara Palma Milla 1
  5. Beatriz Peregrina Cortés 1
  6. Beatriz Santamaría Jaramillo 1
  7. Carmen Gómez Candela 1
  1. 1 Departamento de Nutrición. Hospital Universitario La Paz. Instituto de Investigación Sanitaria del Hospital Universitario La Paz (IdiPaz). Universidad Autónoma de Madrid. Madrid. España.
Journal:
Rev. esp. nutr. comunitaria

ISSN: 1135-3074

Year of publication: 2017

Volume: 23

Issue: 2

Pages: 73-85

Type: Article

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Abstract

Background: Breast cancer (BC) is the most commonlydiagnosed tumor in women and, despite the high cure rates,it continues to be the leading cause of cancer death in thisgroup. Life quality decreases significantly during the treatment of BC and at long term in the growing number of survivors. There is a need to find new adjuvant treatments toincrease survival and/or improve the life quality in thesewomen. There is growing evidence linking the intake of certain foods, or bioactive compounds derived from foods, withbetter prognosis of the disease or improvements in physiological parameters that can increase BC patients’ quality oflife. The aim was gathering and summarizing the availableevidence on the effectiveness of the use of dietary bioactivecompounds as coadjuvants for the BC treatment.Methods: Literature search using Pubmed to identify andanalyze bioactive compounds that could act as coadjvantsfor BC treatment.Results: All tested compounds showed antitumor effectsin vitro. The catechins in green tea have the potential toreduce cardiovascular risk, vitamin D lowers risk of bonefracture, vitamin E could have some effect in the reductionof lymphedema and marine lipids may reduce bone resorption and inflammation.Conclusions: There are bioactive compounds with potential to improve the quality of life of women with BC. Despitethis, there is no sufficient evidence to establish a direct linkbetween the use of these compounds and the tumor progression or patient survival.Key words: Breast Neoplasms. Food. Supplementary feeding.Coadjuvants. Tumor Progression. Bioactive compounds.