Papel del TGFß en la influencia genética a la reabsorción radicular apical externa durante el tratamiento de ortodoncia

Resum

Root resorption is a pathological process of multifactorial origin related to the permanent loss of dental root structure in response to a stimulus mechanical, inflammatory, autoimmune or infectious. In the context of the external apical root resorption secondary to treatment orthodontic (RRAE), genetic predisposition has been described as an etiological factor along with mechanical factors derived from orthodontic treatment. Objetive: to determine whether variants at the level of the coding sequence of the gene of the TGFß, might be associated with a predisposition to suffer RRAE in orthodontics patients. Materials and methods: one hundred and fifty one orthodontic patients from the Master's program of Orthodontics were invited to participate in the study in the University of Seville. All subjects were genotyped, and the clinical factors potentially related to the reabsortive process were collected. Pre and post treatment radiographic projections were used to assess root resorption on maxillary incisors. A binary logistic regression and multiple regression analysis was conducted to determine the degree of influence of each of the included factors (p < .05). Results: the clinical parameters analyzed showed homogeneity of the sample showing no specific association with the RRAE compared to controls (p > .05). The sample of this study presented percentages and distributions allelic and genotypic similar to those observed in the general population. □ espite the evidence referred to in the literature, no association (p > .05) was found between the variants at the level of the TGFB gene and an increased susceptibility to suffer from RRAE secondary to orthodontic treatment. Conclusions: the findings described indicate that inherit a specific a lle le of the TGFB gene is not a determinant of genetic susceptibility to suffer from RRAE in patients undergoing orthodontic treatment.