Quality of life and functional outcomes with tapentadol prolonged release in chronic musculoskeletal pain: <i>post hoc</i> analysis
- Ferri, Cesar Margarit 1
- Natoli, Silvia 5
- Sanz-Ayan, Paz 2
- Magni, Alberto 4
- Guerrero, Carlos 7
- Lara-Solares, Argelia 6
- Liedgens, Hiltrud 3
- Thömmes, Guido 8
- Karra, Ravi 9
-
Sanz Ayán, María Paz
10
- 1 Hospital General Universitario de Alicante, Alicante, 03010, Spain
- 2 Hospital Universitario 12 de Octubre; Department of Rehabilitation, Hospital Universitario 12 de Octubre, Madrid, 28041, Spain
- 3 Global Market Access, Grünenthal GmbH, Aachen, 52099, Germany
- 4 Italian College of General Practitioners & Primary Care, Florence, 50141, Italy
- 5 University of Rome Tor Vergata, Department of Clinical Science & Translational Medicine & Unit of Pain Therapy, Polyclinic of Tor Vergata, Rome, 00133, Italy
- 6 Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, 14080, Mexico
- 7 Hospital Universitario Fundación Santa Fe, Bogotá 110121, Universidad de los Andes, Colombia
- 8 R&D – Development – Data Sciences, Grünenthal GmbH, Aachen, 52099, Germany
- 9 Global Medical Affairs, Grünenthal GmbH, Aachen, 52099, Germany
-
10
Universidad Complutense de Madrid
info
ISSN: 1758-1869, 1758-1877
Año de publicación: 2021
Volumen: 11
Número: 2
Páginas: 173-187
Tipo: Artículo
Otras publicaciones en: Pain Management
Resumen
To investigate quality of life (QOL) and functionality changes in chronic pain during tapentadol prolonged release (PR) treatment. Patients & methods: Post hoc analysis of data from three Phase III trials in patients with osteoarthritis knee pain or low back pain. QOL and functionality changes were assessed by SF-36 scores. Results: All SF-36 subdomain scores improved progressively to week 3 of tapentadol titration and were sustained during 12-week maintenance treatment. Improvements in SF-36 scores were similar between tapentadol dose groups (e.g., 200 to <300 mg vs ≥500 mg), with no greater effect from higher doses. QOL and functionality improvements were consistently greater with tapentadol PR than oxycodone controlled release. Conclusion: Tapentadol PR provides consistent, clinically relevant improvements in QOL and functionality in chronic pain.
Información de financiación
Financiadores
- Grünenthal GmbH
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