COVID-19 y tromboprofilaxisrecomendaciones para nuestra práctica clínica en Atención Primaria
- A. Piera Carbonell 1
- M. Frías Vargas 2
- O. García Vallejo 2
- A. García Lerín 3
- M.A. Cabrera Ferriols 4
- J. Peiró Morant 5
- E. Carrasco Carrasco 6
- 1 Centro de Salud Luanco, Gozón, Asturias, España
- 2 Centro de Salud Comillas, Madrid, España
- 3 Centro de Salud Almendrales, Madrid, España
- 4 Centro de Salud San Vicente del Raspeig, San Vicente del Raspeig, Alicante, España
- 5 Centro de Salud Ponent, Andratx, Mallorca, Illes Balears, España
- 6 Centro de Salud de Abarán, Abarán, Murcia, España
ISSN: 1138-3593
Ano de publicación: 2020
Número: 7
Páxinas: 479-486
Tipo: Artigo
Outras publicacións en: Semergen: revista española de medicina de familia
Resumo
The new coronavirus (SARS-CoV-2) is responsible for a severe acute respiratory syndrome. Among its manifestations, it can develop a thrombotic disease, both venous and arterial, due to excessive inflammation that affects the vascular system, with platelet activation and endothelial dysfunction, among other mechanisms. Thrombosis is associated with SARS-CoV-2 infection, increasing its severity and conferring a worse prognosis. Our performance as Family Physicians can contribute important actions in the management and control of this severe complication. Considering that many of our patients already receive antithrombotic or anticoagulant therapy, the fact that they may develop a COVID-19 infection will have implications for the choice, dosage and control of their treatment. In this document we review, with the information currently available, the relationship between disease caused by SARS-CoV-2 and thrombosis, as well as its management with a focus on Primary Care.
Referencias bibliográficas
- Actualización n.° 160. Enfermedad por el coronavirus (COVID-19), 10 de julio del 2020 [Internet]. Centro de Coordinación de Alertas y Emergencias Sanitarias: España. Ministerio de Sanidad; c2020 [consultado 12 Jul 2020]. Disponible en: https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/Actualizacion_100_COVID-19.pdf Google Scholar
- Z. Varga, A.J. Flammer, P. Steiger, M. Haberecker, R. Andermatt, A. Zinkernagel, et al. Endothelial cell infection and endotheliitis in COVID-19 Lancet., 395 (10234) (2020), pp. 1417-1418, 10.1016/S0140-6736(20)30937-5 ArticleDownload PDFView Record in ScopusGoogle Scholar
- Ministerio de Sanidad. Enfermedad por coronavirus, COVID-19. Madrid: Ministerio de Sanidad; 2020 [actualizado 3 Jul 2020] [citado 12 Jul 2020]. Disponible en: https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/ITCoronavirus.pdf Google Scholar
- J. Cohen The immunopathogenesis of sepsis Nature., 420 (2002), pp. 885-891, 10.1038/nature01326 View Record in ScopusGoogle Scholar
- T. Tanaka, M. Narazaki, T. Kishimoto Immunotherapeutic implications of IL-6 blockade for cytokine storm Immunotherapy., 8 (2016), pp. 959-970, 10.2217/imt-2016-0020 CrossRefView Record in ScopusGoogle Scholar
- S. Yin, M. Huang, D. Li, et al. Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2 J Thromb Thrombolysis [Internet]. (2020), 10.1007/s11239-020-02105-8 Google Scholar
- H. Mei, Y. Hu Characteristics, causes, diagnosis and treatment of coagulation dysfunction in patients with COVID-19 Chin J Hematol., 41 (2020), pp. 185-191, 10.3760/cma.j.issn.0253-2727.2020.0002 View Record in ScopusGoogle Scholar
- H. Han, L. Yang, R. Liu, F. Liu, K.-L. Wu, J. Li, et al. Prominent changes in blood coagulation of patients with SARS-CoV-2 infection Clin Chem Lab Med., 58 (2020), pp. 1116-1120, 10.1515/cclm-2020-0188 CrossRefView Record in ScopusGoogle Scholar
- F. Zhou, T. Yu, R. Du, G. Fan, Y. Liu, Z. Liu, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study Lancet., 395 (2020), pp. 1054-1062, 10.1016/S0140-6736(20)30566-3 ArticleDownload PDFView Record in ScopusGoogle Scholar
- N. Tang, D. Li, X. Wang, Z. Sun Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia J Thromb Haemost., 18 (2020), pp. 844-847, 10.1111/jth.14768 CrossRefView Record in ScopusGoogle Scholar
- F.A. Klok, M.J. Kruip, N.J. Van der Meer, M.S. Arbous, D.A. Gommers, K.M. Kantf, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Thromb Res., 191 (2020), pp. 145-147, 10.1016/j.thromres.2020.04.013 ArticleDownload PDFView Record in ScopusGoogle Scholar
- V. Pallarés, C. Górriz-Zambrano, C. Morillas, J.L. Llisterri, J.L. Gorriz COVID-19 y enfermedad cardiovascular y renal: ¿dónde estamos? ¿Hacia dónde vamos? Semergen [Internet]., 46 (2020), pp. 78-87, 10.1016/j.semerg.2020.05.005 Google Scholar
- E. Terpos, I. Ntanasis-Stathopoulos, I. Elalamy, E. Kastritis, T.N. Sergentanis, M. Politou, et al. Hematological findings and complications of COVID-19 Am J Hematol., 95 (2020), pp. 834-847, 10.1002/ajh.25829 CrossRefView Record in ScopusGoogle Scholar
- M. Arentz, E. Yim, L. Klaff, S. Lokhandwala, F.X. Riedo, M. Chong, et al. Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington State JAMA., 323 (2020), pp. 1612-1614, 10.1001/jama.2020.4326 CrossRefView Record in ScopusGoogle Scholar
- The National Institute for Health and Care Excellence. Venous thromboembolism: Reducing the risk for patients in hospital [Internet]; 2019. [revisado Ago 2019] [consultado 15 abr 2020]. Disponible en: https://www.nice.org.uk/guidance/ng89. Google Scholar
- W. Lim, G. Le Gal, S.M. Bates, M. Righini, L.B. Haramati, E. Lang, et al. American Society of Hematology 2018 guidelines for management of venous thromboembolism: Diagnosis of venous thromboembolism Blood Adv., 2 (2018), pp. 3226-3256, 10.1182/bloodadvances.2018024828 CrossRefView Record in ScopusGoogle Scholar
- J.L. Llisterri La maldita pandemia: una oportunidad para la Atención Primaria de Salud Semergen., 46 (2020), pp. 149-150, 10.1016/j.semerg.2020.03.001 Google Scholar
- S.V. Konstantinides, G. Meyer, C. Becattini, H. Bueno, J.G. Geersing, V.P. Harjola, et al., 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism in collaboration with European Respiratory Society (ERS) Eur Heart J., 41 (2020), pp. 543-603, 10.1093/eurheartj/ehz405 CrossRefView Record in Scopus
- Recomendaciones de tromboprofilaxis y tratamiento antitrombótico en pacientes con COVID-19. Sociedad Española de Trombosis y Hemostasia [on line] [actualizado 21 Abril 2020]. Disponible en: https://www.covid-19.seth.es/recomendaciones-de-tromboprofilaxis-y-tratamiento-antitrombotico-en-pacientes-con-covid-19/ Google Scholar
- S. Barbar, F. Noventa, V. Rossetto, A. Ferrari, B. Brandolin, M. Perlati, et al. A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua Prediction Score J Thromb Haemost., 8 (2010), pp. 2450-2457, 10.1111/j.1538-7836.2010.04044.x CrossRefView Record in ScopusGoogle Scholar
- C. Kearon, J. Omelas, A. Blaivas, D. Jiménez, H. Bounameaux, M. Huisman, et al. Antithrombotic therapy for VTE disease. CHEST Guideline and Expert Panel Report Chest., 149 (2016), pp. 315-352, 10.1016/j.chest.2015.11.026 ArticleDownload PDFView Record in ScopusGoogle Scholar
- R. López, J. Anguis, M. López, L. Giménez, P. Rodríguez, L. Suárez, et al. Escalas de riesgo de enfermedad tromboembólica venosa y su aplicabilidad en pacientes ambulatorios con sospecha de trombosis venosa profunda Actual Med., 104 (Supl.) (2019), pp. 24-60 View Record in ScopusGoogle Scholar
- A.C. Spyropoulos, F. Anderson, G. FitzGerald, H. Decousus, M. Pini, B.H. Chong, et al. Predictive and associative models to identify hospitalized medical patients at risk for VTE Chest., 140 (2011), pp. 706-714, 10.1378/chest.10-1944 ArticleDownload PDFCrossRefView Record in ScopusGoogle Scholar
- A.C. Spyropoulos, C. Lipardi, J. Xu, C. Peluso, T.E. Spiro, Y. De Sanctis, et al. Modified IMPROVE VTE Risk Score and elevated d-dimer identify a high venous thromboembolism risk in acutely ill medical population for extended Thromboprophylaxis TH Open., 04 (2020), pp. e59-e65, 10.1055/s-0040-1705137 View Record in ScopusGoogle Scholar
- S.R. Kahn, W. Lim, A.S. Dunn, M. Cushman, F. Dentali, E.A. Akl, et al. Prevention of VTE in nonsurgical patients. Antithrombotic therapy and prevention on of thrombosis. 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines Chest., 141 (Suppl) (2012), pp. e195S-226S, 10.1378/chest.11-2296 CrossRefGoogle Scholar
- Sociedad Española de Trombosis y Hemostasia. Madrid: Sociedad Española de Trombosis y Hemostasia [actualizado 21 Abril 2020] [consultado 27 Abril 2020]. Disponible en: https://www.covid-19.seth.es/wp-content/uploads/2020/04/Recomendaciones-tromboprofilaxis-y-tratamiento-antitrombotico-pacientes-COVID-19_2020-04-29.pdf Google Scholar 27 Z. Zhai, C. Li, Y. Chen, G. Gerotziafas, Z. Zhang, J. Wan, et al. Prevention and Treatment of venous thromboembolism associated with coronavirus disease 2019 infection: A consensus statement before guidelines Thromb Haemost [Internet]., 120 (2020), pp. 937-948 [consultado 22 Abril 2020]. Disponible en: https://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1710019.pdf https://doi.org/10.1055/s-0040-1710019 CrossRefView Record in ScopusGoogle Scholar
- A. Cuker, G.M. Arepally, B.H. Chong, D.B. Cines, A. Greinacher, Y. Gruel, et al. American Society of Hematology 2018 guidelines for management of venous thromboembolism: Heparin-induced thrombocytopenia Blood Adv., 2 (2018), pp. 3360-3392, 10.1182/bloodadvances.2018024489 CrossRefView Record in ScopusGoogle Scholar
- Y.M. Arabi, F. Al-Hameed, K.E.A. Burns, S. Mehta, S. Alsolamy, M.S. ALshahrani, et al., Saudi Critical Care Trials Group Adjunctive intermittent pneumatic compression for venous thromboprophylaxis N Engl J Med., 380 (2019), pp. 1305-1315, 10.1056/NEJMoa1816150 CrossRefView Record in ScopusGoogle Scholar
- J.L. Gallo-Vallejo, M. Naveiro-Fuentes, A. Puertas-Prieto, F.J. Gallo-Vallejo Prevención del tromboembolismo venoso durante el embarazo y el puerperio en Atención Primaria y Especializada Semergen., 43 (2017), pp. 450-456, 10.1016/j.semerg.2016.08.001 ArticleDownload PDFView Record in ScopusGoogle Scholar
- E. Driggin, M.V. Madhavan, B. Bikdeli, T. Chuich, J. Laracy, G. Biondi-Zoccai, et al. Cardiovascular considerations for patients, health care workers, and health systems during the coronavirus disease 2019 (COVID-19) pandemic J Am Coll Cardiol., 75 (2020), pp. 2352-2371, 10.1016/j.jacc.2020.03.031 ArticleDownload PDFView Record in ScopusGoogle Scholar
- D. Vivas, V. Roldán, M.A. Esteve-Pastor, I. Roldán, A. Tello-Montoliu, J.M. Ruiz-Nodar, et al. Recomendaciones sobre el tratamiento antitrombótico durante la pandemia COVID-19. posicionamiento del Grupo de Trabajo de Trombosis Cardiovascular de la Sociedad Española de Cardiología Rev Esp Cardiol., 73 (2020), pp. 749-757 [consultado 22 abr 2020]. Disponible en: https://www.sciencedirect.com/science/article/pii/S0300893220302062?via%3Dihub https://doi.org/10.1016/j.recesp.2020.04.006 ArticleDownload PDFView Record in ScopusGoogle Scholar
- B. Bikdeli, M. Madhavan, D. Jiménez, T. Chuich, I. Dreyfus, E. Driggin, et al. COVID-19 and thrombotic or thromboembolic disease: Implications for prevention, antithrombotic therapy, and follow-up J Am Coll Cardiol., 75 (2020), pp. 2352-2371 [consultado 15 Abril 2020]. Disponible en: https://www.sciencedirect.com/science/article/pii/S0735109720350087. Google Scholar
- H.O. Al-Shamsi, W. Alhazzani, A. Alhuraiji, E.A. Coomes, R.F. Chemaly, M. Almuhanna, et al. A practical approach to the management of cancer patients during the novel coronavirus disease 2019 (COVID-19) pandemic: An International Collaborative Group Oncologist, 25 (2020), pp. e936-e945, 10.1634/theoncologist.2020-0213 View Record in ScopusGoogle Scholar
- L. Reina, J.E. Carrasco, M.D. Aicart, J. Archilla, C.A. Barrio, J.J. Baztán, et al. Recomendaciones sobre profilaxis, diagnóstico y tratamiento de la enfermedad tromboembólica venosa en Atención Primaria: documento de consenso CEFyL, SEMERGEN Capítulo Español de Flebología y Linfología Editores Médicos, Madrid (2014) Google Scholar