Factores cardiometabólicos asociados y prevalencia de concentraciones bajas de colesterol HDL y de dislipidemia aterogénica. Estudio SIMETAP-DA
- Ruiz-García, Antonio
- Arranz-Martínez, Ezequiel
- García-Fernández, María E. 1
- Cabrera-Vélez, Roberto
- García-Pliego, Rosa A. 1
- Morales-Cobos, Luis E. 2
- Sanz-Pozo, Blanca
- Gómez-Díaz, Esther
- Rodríguez-de-Mingo, Enrique
- Rico-Pérez, María R. 3
- Migueláñez-Valero, Alfonso
- Calderín-Morales, María P. 4
- Sandín-de-Vega, Eloína 4
- Hombrados-Gonzalo, María P. 5
- Luna-Ramírez, Sonia 6
- Sánchez-Ramos, María C. 6
- Mora-Casado, Cristina 7
- Moreno-Muñoz, María S. 8
- González-Escobar, Paloma 9
- Ruiz-Díaz, Lourdes 10
- Caballero-Ramírez, Nuria 11
- Zamora-Gómez, María M. 11
- Iturmendi-Martínez, Nerea 12
- Holgado-Catalán, María S. 13
- Álvarez-Benedicto, Rebeca 13
- Sanchidriá-Fernández, Pedro L. 14
- Benito-Alonso, Elena 1
- Fernández-Vicente, Teresa 15
- Hernández-López, Rosa M. 16
- Doria-Carlin, Norma A. 17
- Frías-Vargas, Manuel J. 18
- Mostra tots els autors/es +
- 1 C.S. Griñón, Griñón, España
- 2 C.S. Universitario Las Américas, Parla, España
- 3 Unidad de Lípidos y Prevención Cardiovascular, C.S. Universitario Pinto, Pinto, España
- 4 C.S. Las Ciudades, Getafe, España
- 5 C.S. Reyes Magos, Madrid, España
- 6 C.S. Eloy Gonzalo, Madrid, España
- 7 C.S. Maqueda, Madrid, España
- 8 C.S. Federica Montseny, Madrid, España
- 9 C.S. Buenos Aires, Madrid, España
- 10 C.S. Valleaguado, Coslada, España
- 11 C.S. Juncal, Torrejón de Ardoz, España
- 12 C.S. General Fanjul, Madrid, España
- 13 C.S. Monterrozas, Las Rozas de Madrid, España
- 14 C.S. Aravaca, Madrid, España
- 15 C.S. Universitario Sector III, Getafe, España
- 16 C.S. Getafe Norte, Getafe, España
- 17 C.S. Los Cármenes, Madrid, España
- 18 C.S. Comillas, Madrid, España
ISSN: 0214-9168, 1578-1879
Any de publicació: 2021
Volum: 33
Número: 1
Pàgines: 19-29
Tipus: Article
Altres publicacions en: Clínica e investigación en arteriosclerosis
Resum
Aim To determine the crude and sex- and age-adjusted prevalence rates of atherogenic dyslipidemia (AD) and low HDL-cholesterol levels (low-HDLc), and to assess their associations with cardiovascular risk factors, chronic kidney disease, cardiovascular and cardiometabolic diseases. Methods Population-based cross-sectional study conducted in Primary Care, with randomly selected adult subjects. The AD was considered if the patients had hypertriglyceridemia (triglycerides ≥ 150 mg/dL) and low-HDLc (< 40 mg/dL [men]; < 50 mg/dL [women]). Crude and sex- and age-adjusted prevalence rates were determined, and univariate and multivariate analysis were performed to assess related cardiometabolic factors. Results Study population with 6,588 adults (55.9% women) with mean age 55.1 (± 17.5) years. The mean HDLc levels were 49.2 (± 12.6) mg/dL in men and 59.2 (± 14.7) mg/dL in women. The crude prevalence rates of low-HDLc and AD were 30.8% (95%CI: 29.7-31.9), and 14.3% (95%CI: 13.5-15.2), respectively. The adjusted prevalence rates of low-HDLc were 28.0% in men and 31.0% in women, and AD were 16.4% in men and 10.6% in women. Seventy-three percent of the population with AD had high or very high cardiovascular risk. The independent factors associated with low HDLc or with AD were diabetes, smoking, abdominal obesity, and obesity. The major factors associated with low HDLc and AD were hypertriglyceridemia and diabetes, respectively. Conclusions Almost a third of the adult population had low HDL-C and half of them met AD criteria. Cardiometabolic factors were associated with low HDL-C and AD, highlighting hypertriglyceridemia with low HDLc, and DM with AD.