European Medical Education Initiative on Noonan syndrome: A clinical practice survey assessing the diagnosis and clinical management of individuals with Noonan syndrome across Europe

  1. García-Miñaúr, Sixto
  2. Burkitt-Wright, Emma
  3. Verloes, Alain
  4. Shaikh, Guftar
  5. Lebl, Jan
  6. Östman-Smith, Ingegerd
  7. Wolf, Cordula M.
  8. Ortega Castelló, Eduardo
  9. Tartaglia, Marco
  10. Zenker, Martin
  11. Edouard, Thomas
Revista:
European Journal of Medical Genetics

ISSN: 1769-7212

Año de publicación: 2022

Volumen: 65

Número: 1

Páginas: 104371

Tipo: Artículo

DOI: 10.1016/J.EJMG.2021.104371 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: European Journal of Medical Genetics

Resumen

IntroductionNoonan syndrome (NS) is a rare genetic disorder caused by mutations in genes encoding components of the RAS/mitogen-activated protein kinase (MAPK) signalling pathway. Patients with NS exhibit certain characteristic features, including cardiac defects, short stature, distinctive facial appearance, skeletal abnormalities, cognitive deficits, and predisposition to certain cancers. Here, a clinical practice survey was developed to learn more about differences in the diagnosis and management of this disease across Europe. The aim was to identify gaps in the knowledge and management of this rare disorder.Materials and methodsThe European Medical Education Initiative on NS, which comprised a group of 10 experts, developed a 60-question clinical practice survey to gather information from European physicians on the diagnosis and clinical management of patients with diseases in the NS phenotypic spectrum. Physicians from three specialities (clinical genetics, paediatric endocrinology, paediatric cardiology) were invited to complete the survey by several national and European societies. Differences in answers provided by respondents between specialities and countries were analysed using contingency tables and the Chi-Squared test for independence. The Friedman's test was used for related samples.ResultsData were analysed from 364 respondents from 20 European countries. Most respondents came from France (21%), Spain (18%), Germany (16%), Italy (15%), United Kingdom (8%) and the Czech Republic (6%). Respondents were distributed evenly across three specialities: clinical genetics (30%), paediatric endocrinology (40%) and paediatric cardiology (30%). Care practices were generally aligned across the countries participating in the survey. Delayed diagnosis did not emerge as a critical issue, but certain unmet needs were identified, including transition of young patients to adult medical services and awareness of family support groups.ConclusionData collected from this survey provide a comprehensive summary of the diagnosis and clinical management practices for patients with NS across different European countries.

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