OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives

  1. Sánchez-Puebla, Lidia 1
  2. López-Cuenca, Inés 112
  3. Salobrar-García, Elena 112
  4. Ramírez, Ana I. 112
  5. Fernández-Albarral, José A. 12
  6. Matamoros, José A. 11
  7. Elvira-Hurtado, Lorena 1
  8. Salazar, Juan J. 112
  9. Ramírez, José M. 112
  10. de Hoz, Rosa 112
  1. 1 Universidad Complutense de Madrid
    info

    Universidad Complutense de Madrid

    Madrid, España

    ROR 02p0gd045

  2. 2 Hospital Clínico San Carlos de Madrid
    info

    Hospital Clínico San Carlos de Madrid

    Madrid, España

    ROR https://ror.org/04d0ybj29

Revista:
Biomedicines

ISSN: 2227-9059

Año de publicación: 2024

Volumen: 12

Número: 3

Páginas: 528

Tipo: Artículo

DOI: 10.3390/BIOMEDICINES12030528 GOOGLE SCHOLAR lock_openDocta Complutense editor

Otras publicaciones en: Biomedicines

Resumen

The murine models of Alzheimer’s disease (AD) have advanced our understanding of the pathophysiology. In vivo studies of the retina using optical coherence tomography (OCT) have complemented histological methods; however, the lack of standardisation in OCT methodologies for murine models of AD has led to significant variations in the results of different studies. A literature search in PubMed and Scopus has been performed to review the different methods used in these models using OCT and to analyse the methodological characteristics of each study. In addition, some recommendations are offered to overcome the challenges of using OCT in murine models. The results reveal a lack of consensus on OCT device use, retinal area analysed, segmentation techniques, and analysis software. Although some studies use the same OCT device, variations in other parameters make the direct comparison of results difficult. Standardisation of retinal analysis criteria in murine models of AD using OCT is crucial to ensure consistent and comparable results. This implies the application of uniform measurement and segmentation protocols. Despite the absence of standardisation, OCT has proven valuable in advancing our understanding of the pathophysiology of AD.

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