Evaluación de la motilidad del intestino delgado mediante manometría intestinal de alta resolución

Résumé

Gastrointestinal motility studies using manometry equipments were developed to improve our understanding of the physiology and pathophysiology of the digestive tract, but in recent years, manometric studies have been found to be clinically useful for the evaluation of patients with suspected motor disorders. In clinical practice, manometry studies are an important technique for the evaluation of gastrointestinal motility, especially for evaluating esophageal and anorectal motility. In the last two decades, the development of high-resolution manometry equipment, which consisted of multiple pressure sensors separated by small spaces (1-2 cm) from each other and the analysis of the records by visualization of “contour plot” to represent pressure-space-time events have revolutionized the way of understanding and evaluating the motility of the digestive organs. However, at present, the study of small intestine motility with manometry is only performed in reference centers worldwide, and conventional manometry is still used. In this thesis, a high resolution intestinal manometry equipment has been developed, with 34 sensors separated by 1 cm to evaluate intestinal motility. Experiments have been performed in healthy subjects to describe the characteristics of normal intestinal motility using high-resolution intestinal manometry both in the fasted and postprandial period, and also the results of a single-blind controlled clinical trial in order to evaluate the ability of high-resolution intestinal manometry to detect changes in the motor patterns of the small intestine.