Indium-Mediated Preparation of Bis(α-hydroxyallenes) or α,α′-Dihydroxyallenynes and Further Gold-Catalyzed Cyclizations
- Martínez del Campo, Teresa 1
- San Martín, Daniel 1
- Gamarra, Laura 1
- Cerrón, Eva 1
- Cembellín, Sara 1
- Yanai, Hikaru 2
- Almendros, Pedro 3
- 1 Grupo de Lactamas y Heterociclos Bioactivos, Departamento de Química Orgánica, Unidad Asociada al CSIC, Facultad de Química, Universidad Complutense de Madrid, Madrid 28040, Spain
- 2 School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji ,Tokyo192-0392, Japan
- 3 Instituto de Química Orgánica General, IQOG, CSIC, Juan de la Cierva 3, Madrid 28006, Spain
ISSN: 0022-3263, 1520-6904
Ano de publicación: 2024
Tipo: Artigo
Outras publicacións en: The Journal of Organic Chemistry
Resumo
We present the regio- and diastereoselective Barbier-type allenylation reaction of glyoxals mediated by indium to furnish highly valuable syn-bis(α-hydroxyallenes) and syn-α,α′-dihydroxyallenynes. The gold-catalyzed controlled cyclization of these unsaturated diols enables the divergent preparation of three types of oxacycles.
Información de financiamento
Financiadores
-
Universidad Complutense de Madrid
- PR3/23-30806
-
Japan Society for the Promotion of Science
- 23K06031
-
Ministerio de Ciencia e Innovaci?n
- PID2021-122183NB-C21
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