Enhanced Production of Therapeutic Metabolites in Cork-Oak Somatic Embryos under Abiotic Stress Conditions

  1. López, Beatriz Pintos 1
  2. Manzanera, José Antonio 2
  3. Pérez-Urria, Elena 1
  4. Jiménez, Carlos 1
  5. Montoro, Alba 1
  6. Gomez-Garay, Arancha 1
  1. 1 Research Group FiVe-A, Plant Physiology Unit, Faculty of Biology, Universidad Complutense de Madrid, Ciudad Universitaria, 28040 Madrid, Spain
  2. 2 Research Group FiVe-A, College of Forestry and Natural Environment, Universidad Politécnica de Madrid, Ciudad Universitaria, 28040 Madrid, Spain
Revista:
Stresses

ISSN: 2673-7140

Any de publicació: 2024

Volum: 4

Número: 3

Pàgines: 546-557

Tipus: Article

DOI: 10.3390/STRESSES4030035 GOOGLE SCHOLAR lock_openAccés obert editor

Altres publicacions en: Stresses

Resum

This study investigates the enhanced production of key therapeutic metabolites (ellagic acid, serotonin, and chlorogenic acid) in response to abiotic stress in in vitro cultures of Quercus suber somatic embryos. Findings indicate significant increases in metabolite levels under various stress conditions, highlighting the potential for commercial-scale production of these compounds, known for their antioxidant, anticancer, and anti-COVID-19 properties. Under osmotic/saline stress,ellagic acid production significantly increased, representing an 80% increase compared to control conditions. In embryos exposed to different stressors, serotonin accumulation showed a six-fold increase under smotic/saline stress. Although the elicitors used did not increase chlorogenic acid levels, exploring alternative stress types may enhance its production. This research paves the way for sustainable, large-scale production of health-beneficial metabolites, addressing global health challenges and promoting resource sustainability.

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