Publicaciones en las que colabora con María José Morcillo Ortega (36)

2005

  1. Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT1AR agonists with selectivity over α1- adrenoceptors

    Journal of Medicinal Chemistry, Vol. 48, Núm. 7, pp. 2548-2558

2004

  1. Serotonin 5-HT 7 receptor antagonists

    Current Medicinal Chemistry - Central Nervous System Agents, Vol. 4, Núm. 3, pp. 203-214

  2. Benzimidazole derivatives. Part 5: Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT 1A/5-HT 3 ligands

    Bioorganic and Medicinal Chemistry, Vol. 12, Núm. 19, pp. 5181-5191

2003

  1. Optimization of the Pharmacophore Model for 5-HT 7 R Antagonism. Design and Synthesis of New Naphtholactam and Naphthosultam Derivatives

    Journal of Medicinal Chemistry, Vol. 46, Núm. 26, pp. 5638-5650

  2. Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2- a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist

    Bioorganic and Medicinal Chemistry Letters, Vol. 13, Núm. 8, pp. 1429-1432

  3. Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands

    Bioorganic and Medicinal Chemistry Letters, Vol. 13, Núm. 19, pp. 3177-3180

2002

  1. 5-HT(4) receptor antagonists: structure-affinity relationships and ligand-receptor interactions.

    Current topics in medicinal chemistry, Vol. 2, Núm. 6, pp. 625-641

  2. Arylpiperazine derivatives acting at 5-HT1A receptors

    Current Medicinal Chemistry, Vol. 9, Núm. 4, pp. 443-469

2001

  1. Biochemical, electrophysiological and neurohormonal studies with B-20991, a selective 5-HT1A receptor agonist

    Pharmacology, Vol. 62, Núm. 4, pp. 234-242

  2. Synthesis and structure-activity relationships of a new model of arylpiperazines. 5. Study of the physicochemical influence of the pharmacophore on 5-HT1A/α1-adrenergic receptor affinity: Synthesis of a new derivative with mixed 5-HT1A/D2 antagonist properties

    Journal of Medicinal Chemistry, Vol. 44, Núm. 2, pp. 186-197

  3. Synthesis and structure-activity relationships of a new model of arylpiperazines. 6. Study of the 5-HT1A/α1-adrenergic receptor affinity by classical Hansch analysis, artificial neural networks, and computational simulation of ligand recognition

    Journal of Medicinal Chemistry, Vol. 44, Núm. 2, pp. 198-207

2000

  1. First pharmacophoric hypothesis for 5-HT 7 antagonism

    Bioorganic and Medicinal Chemistry Letters, Vol. 10, Núm. 10, pp. 1097-1100

1999

  1. Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT3 receptors

    Journal of Medicinal Chemistry, Vol. 42, Núm. 24, pp. 5020-5028

  2. Benzimidazole derivatives. Part 1: Synthesis and structure-activity relationships of new benzimidazole-4-carboxamides and carboxylates as potent and selective 5-HT4 receptor antagonists

    Bioorganic and Medicinal Chemistry, Vol. 7, Núm. 11, pp. 2271-2281

  3. Design and synthesis of 2-[4-[4-(m-(ethylsulfonamido)-phenyl)piperazin- 1-yl]butyl]-1,3-dioxoperhydropyrrolo[1,2c]imidazole (EF-7412) using neural networks. A selective derivative with mixed 5-HT(1A)/D2 antagonist properties

    Bioorganic and Medicinal Chemistry Letters, Vol. 9, Núm. 12, pp. 1679-1682

  4. Synthesis and structure-activity relationships of a new model of arylpiperazines 4. 1-[ω-(4-Arylpiperazin-1-yl)alkyl]-3-(diphenylmethylene)- 2,5-pyrrolidinediones and -3-(9h-fluoren-9-ylidene)-2,5-pyrrolidinediones: Study of the steric requirements of the terminal amide fragment on 5-HT(1A) affinity/selectivity

    Journal of Medicinal Chemistry, Vol. 42, Núm. 1, pp. 36-49

1998

  1. 1-[ω-(4-arylpiperazin-1-yl)alkyl]-3-diphenylmethylene-2,5-pyrrolidinediones as 5-HT(1A) receptor ligands: Study of the steric requirements of the terminal amide fragment on 5-HT(1A) affinity/selectivity

    Bioorganic and Medicinal Chemistry Letters, Vol. 8, Núm. 6, pp. 581-586

  2. Preclinical pharmacology of B-20991, a 5-HT(1A) receptor agonist with anxiolytic activity

    European Journal of Pharmacology, Vol. 344, Núm. 2-3, pp. 127-135

1997

  1. Comparative receptor mapping of serotoninergic 5-HT3 and 5-HT4 binding sites

    Journal of Computer-Aided Molecular Design, Vol. 11, Núm. 6, pp. 589-599

  2. Synthesis and structure-activity relationships of a new model of arylpiperazines. 2. Three-dimensional quantitative structure-activity relationships of hydantoin-phenylpiperazine derivatives with affinity for 5- HT(1A) and α1 receptors. A comparison of CoMFA models

    Journal of Medicinal Chemistry, Vol. 40, Núm. 11, pp. 1648-1656