Publicaciones en colaboración con investigadores/as de Universitat Autònoma de Barcelona (23)

2022

  1. Novel Antagonist of the Type 2 Lysophosphatidic Acid Receptor (LPA2), UCM-14216, Ameliorates Spinal Cord Injury in Mice

    Journal of Medicinal Chemistry, Vol. 65, Núm. 16, pp. 10956-10974

2019

  1. A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia

    Journal of Medicinal Chemistry, Vol. 62, Núm. 13, pp. 6035-6046

2017

  1. A new serotonin 5-HT 6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding

    Scientific Reports, Vol. 7

  2. Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling

    Chemistry - A European Journal, Vol. 23, Núm. 7, pp. 1676-1685

  3. Ligand chain length drives activation of lipid G protein-coupled receptors

    Scientific Reports, Vol. 7, Núm. 1

2014

  1. Serotonin 5-HT6receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease

    Journal of Medicinal Chemistry, Vol. 57, Núm. 17, pp. 7160-7181

  2. The extracellular entrance provides selectivity to serotonin 5-HT 7 receptor antagonists with antidepressant-like behavior in vivo

    Journal of Medicinal Chemistry, Vol. 57, Núm. 15, pp. 6879-6884

2013

  1. Insights into the glycosaminoglycan-mediated cytotoxic mechanism of eosinophil cationic protein revealed by NMR

    ACS Chemical Biology, Vol. 8, Núm. 1, pp. 144-151

2012

  1. Chemical probes for the recognition of cannabinoid receptors in native systems

    Angewandte Chemie - International Edition, Vol. 51, Núm. 28, pp. 6896-6899

2011

  1. Development of non-peptide ligands of growth factor receptor-bound protein 2-src homology 2 domain using molecular modeling and NMR spectroscopy

    Journal of Medicinal Chemistry, Vol. 54, Núm. 4, pp. 1096-1100

  2. The importance of solvation in the design of ligands targeting membrane proteins

    MedChemComm, Vol. 2, Núm. 3, pp. 160-164

2010

  1. Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation

    Journal of Medicinal Chemistry, Vol. 53, Núm. 3, pp. 1357-1369

2009

  1. Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-ht7/5-ht1a receptor selectivity

    Journal of Medicinal Chemistry, Vol. 52, Núm. 8, pp. 2384-2392

2007

  1. Structural models of class A G protein-coupled receptors as a tool for drug design: Insights on transmembrane bundle plasticity

    Current Topics in Medicinal Chemistry, Vol. 7, Núm. 10, pp. 991-998

  2. The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptors

    ChemBioChem

2004

  1. Serotonin 5-HT 7 receptor antagonists

    Current Medicinal Chemistry - Central Nervous System Agents, Vol. 4, Núm. 3, pp. 203-214

2003

  1. Benzimidazole derivatives.4. The recognition of the voluminous substituent attached to the basic amino group of 5-HT4 receptor antagonists

    Journal of Computer-Aided Molecular Design, Vol. 17, Núm. 8, pp. 515-524

2002

  1. Benzimidazole derivatives. 3. 3D-QSAR/CoMFA model and computational simulation for the recognition of 5-HT4 receptor antagonists

    Journal of Medicinal Chemistry, Vol. 45, Núm. 22, pp. 4806-4815

  2. Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine1a receptor ligands to explore the three-dimensional structure of the receptor

    Molecular Pharmacology, Vol. 62, Núm. 1, pp. 15-21

2001

  1. 3-D-QSAR/CoMFA and recognition models of benzimidazole derivatives at the 5-HT(4) receptor

    Bioorganic and medicinal chemistry letters, Vol. 11, Núm. 21, pp. 2807-2811