Química médica y biológica - MedChemLab
QUÍMICA MÉDICA
Universitat Autònoma de Barcelona
Barcelona, EspañaPublicaciones en colaboración con investigadores/as de Universitat Autònoma de Barcelona (23)
2022
-
Novel Antagonist of the Type 2 Lysophosphatidic Acid Receptor (LPA2), UCM-14216, Ameliorates Spinal Cord Injury in Mice
Journal of Medicinal Chemistry, Vol. 65, Núm. 16, pp. 10956-10974
2019
-
A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia
Journal of Medicinal Chemistry, Vol. 62, Núm. 13, pp. 6035-6046
2017
-
A new serotonin 5-HT 6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding
Scientific Reports, Vol. 7
-
Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling
Chemistry - A European Journal, Vol. 23, Núm. 7, pp. 1676-1685
-
Ligand chain length drives activation of lipid G protein-coupled receptors
Scientific Reports, Vol. 7, Núm. 1
2014
-
Serotonin 5-HT6receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease
Journal of Medicinal Chemistry, Vol. 57, Núm. 17, pp. 7160-7181
-
The extracellular entrance provides selectivity to serotonin 5-HT 7 receptor antagonists with antidepressant-like behavior in vivo
Journal of Medicinal Chemistry, Vol. 57, Núm. 15, pp. 6879-6884
2013
-
Insights into the glycosaminoglycan-mediated cytotoxic mechanism of eosinophil cationic protein revealed by NMR
ACS Chemical Biology, Vol. 8, Núm. 1, pp. 144-151
2012
-
Chemical probes for the recognition of cannabinoid receptors in native systems
Angewandte Chemie - International Edition, Vol. 51, Núm. 28, pp. 6896-6899
2011
-
Development of non-peptide ligands of growth factor receptor-bound protein 2-src homology 2 domain using molecular modeling and NMR spectroscopy
Journal of Medicinal Chemistry, Vol. 54, Núm. 4, pp. 1096-1100
-
The importance of solvation in the design of ligands targeting membrane proteins
MedChemComm, Vol. 2, Núm. 3, pp. 160-164
2010
-
Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation
Journal of Medicinal Chemistry, Vol. 53, Núm. 3, pp. 1357-1369
2009
-
Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-ht7/5-ht1a receptor selectivity
Journal of Medicinal Chemistry, Vol. 52, Núm. 8, pp. 2384-2392
2007
-
Structural models of class A G protein-coupled receptors as a tool for drug design: Insights on transmembrane bundle plasticity
Current Topics in Medicinal Chemistry, Vol. 7, Núm. 10, pp. 991-998
-
The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptors
ChemBioChem
2004
-
Serotonin 5-HT
7
receptor antagonists
Current Medicinal Chemistry - Central Nervous System Agents, Vol. 4, Núm. 3, pp. 203-214
2003
-
Benzimidazole derivatives.4. The recognition of the voluminous substituent attached to the basic amino group of 5-HT4 receptor antagonists
Journal of Computer-Aided Molecular Design, Vol. 17, Núm. 8, pp. 515-524
2002
-
Benzimidazole derivatives. 3. 3D-QSAR/CoMFA model and computational simulation for the recognition of 5-HT4 receptor antagonists
Journal of Medicinal Chemistry, Vol. 45, Núm. 22, pp. 4806-4815
-
Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine1a receptor ligands to explore the three-dimensional structure of the receptor
Molecular Pharmacology, Vol. 62, Núm. 1, pp. 15-21
2001
-
3-D-QSAR/CoMFA and recognition models of benzimidazole derivatives at the 5-HT(4) receptor
Bioorganic and medicinal chemistry letters, Vol. 11, Núm. 21, pp. 2807-2811