Publicacións nas que colabora con J. Egea (32)

2022

  1. Synthesis and Pharmacological Evaluation of New N-Sulfonylureas as NLRP3 Inflammasome Inhibitors: Identification of a Hit Compound to Treat Gout

    Journal of Medicinal Chemistry, Vol. 65, Núm. 8, pp. 6250-6260

2021

  1. Privileged quinolylnitrones for the combined therapy of ischemic stroke and alzheimer’s disease

    Pharmaceuticals, Vol. 14, Núm. 9

2020

  1. In Vitro and in Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases

    ACS Chemical Neuroscience, Vol. 11, Núm. 22, pp. 3793-3801

  2. Na+ controls hypoxic signalling by the mitochondrial respiratory chain

    Nature, Vol. 586, Núm. 7828, pp. 287-291

2019

  1. New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition

    Journal of Medicinal Chemistry, Vol. 62, Núm. 24, pp. 11416-11422

  2. Quinoxalinetacrine QT78, a cholinesterase inhibitor as a potential ligand for Alzheimer’s disease therapy

    Molecules, Vol. 24, Núm. 8

2018

  1. Analysis of gene expression profiles of CR80, a neuroprotective 1,8-Naphthyridine

    Future Medicinal Chemistry, Vol. 10, Núm. 11, pp. 1289-1300

  2. Corrigendum to “European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)” (Redox Biol. (2017) 13 (94–162)(S2213231717303373)(10.1016/j.redox.2017.05.007))

    Redox Biology

  3. Folic Acid Protects Against Glutamate-Induced Excitotoxicity in Hippocampal Slices Through a Mechanism that Implicates Inhibition of GSK-3β and iNOS

    Molecular Neurobiology, Vol. 55, Núm. 2, pp. 1580-1589

2017

  1. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

    Redox Biology, Vol. 13, pp. 94-162

  2. Ischemic brain injury: New insights on the protective role of melatonin

    Free Radical Biology and Medicine, Vol. 104, pp. 32-53

  3. Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration

    Future Medicinal Chemistry, Vol. 9, Núm. 8, pp. 765-780

  4. Mitochondrial complex I deactivation is related to superoxide production in acute hypoxia

    Redox Biology, Vol. 12, pp. 1040-1051

  5. Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases

    Angewandte Chemie - International Edition, Vol. 56, Núm. 41, pp. 12765-12769

2016

  1. Melatonin protects against oxygen and glucose deprivation by decreasing extracellular glutamate and Nox-derived ROS in rat hippocampal slices

    NeuroToxicology, Vol. 57, pp. 61-68

  2. The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators

    Journal of Medicinal Chemistry, Vol. 59, Núm. 21, pp. 9967-9973

2015

  1. Both creatine and its product phosphocreatine reduce oxidative stress and afford neuroprotection in an in vitro Parkinson’s model

    ASN Neuro, Vol. 6, Núm. 6

  2. Novel tacrine-grafted ugi adducts as multipotent anti-alzheimer drugs: A synthetic renewal in tacrine-ferulic acid hybrids

    ChemMedChem, Vol. 10, Núm. 3, pp. 523-539

2014

  1. ITH12410/SC058: A new neuroprotective compound with potential in the treatment of Alzheimer's disease

    ACS Chemical Neuroscience, Vol. 5, Núm. 9, pp. 770-775

2013

  1. Enantioselective neuroprotective effects of tacripyrine ITH122 against oxygen and glucose deprivation in rat hippocampal slices

    CNS Neuroscience and Therapeutics