Neurotransmisión y neurorreparación
Universidade de Lisboa
Lisboa, PortugalPublicacións en colaboración con investigadores/as de Universidade de Lisboa (36)
2021
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Five-Membered-Ring-Fused Tacrines as Anti-Alzheimer's Disease Agents
Synlett, Vol. 32, Núm. 20, pp. 1987-2012
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Synthesis and Fluorescence of (E)-3-Aryl-2-(5-aryl-4H-1,2,4-triazol-3-yl) Acrylonitriles
ChemistrySelect, Vol. 6, Núm. 25, pp. 6360-6364
2020
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Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy
Bioorganic and Medicinal Chemistry Letters, Vol. 30, Núm. 3
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Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds: Exploring multiple activities as anti-Alzheimer agents
Drug Development Research, Vol. 81, Núm. 2, pp. 215-231
2019
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Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer’s disease therapy
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 34, Núm. 1, pp. 163-170
2017
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European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
Redox Biology, Vol. 13, pp. 94-162
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Multitarget-Directed Antioxidants as Therapeutic Agents: Putting the Focus on the Oxidative Stress
Design of Hybrid Molecules for Drug Development (Elsevier Inc.), pp. 5-46
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eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1
PLoS Biology, Vol. 15, Núm. 4
2016
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ASS234, as a new multi-target directed propargylamine for Alzheimer's disease therapy
Frontiers in Neuroscience, Vol. 10, Núm. JUN
2015
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Predicting targets of compounds against neurological diseases using cheminformatic methodology
Journal of Computer-Aided Molecular Design, Vol. 29, Núm. 2, pp. 183-198
2014
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Exploring the structural basis of the selective inhibition of monoamine oxidase A by dicarbonitrile aminoheterocycles: Role of Asn181 and Ile335 validated by spectroscopic and computational studies
Biochimica et Biophysica Acta - Proteins and Proteomics, Vol. 1844, Núm. 2, pp. 389-397
2013
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Multipotent 1,8-naphthyridines, as new tacrine analogues, for the treatment of Alzheimer's disease
Bioactive Heterocycles: Synthesis and Biological Evaluation (Nova Science Publishers, Inc.), pp. 1-18
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Nitrosothiols in the immune system: Signaling and protection
Antioxidants and Redox Signaling, Vol. 18, Núm. 3, pp. 288-308
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Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: Effect against amyloid-β-induced neurotoxicity
ACS Chemical Neuroscience, Vol. 4, Núm. 4, pp. 547-565
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The multifactorial nature of Alzheimer's disease for developing potential therapeutics
Current Topics in Medicinal Chemistry, Vol. 13, Núm. 15, pp. 1745-1770
2011
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A practical two-step synthesis of imidazo[1,2-a]pyridines from N-(prop-2-yn-1-yl)pyridin-2-amines
Chemical Communications, Vol. 47, Núm. 17, pp. 5043-5045
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Microwave irradiation-assisted amination of 2-chloropyridine derivatives with amide solvents
Synthetic Communications, Vol. 41, Núm. 19, pp. 2859-2869
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Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues
European Journal of Medicinal Chemistry, Vol. 46, Núm. 12, pp. 6119-6130
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Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives
European Journal of Medicinal Chemistry, Vol. 46, Núm. 9, pp. 4676-4681