Neurotransmisión y neurorreparación
Instituto de Química Médica
Madrid, EspañaPublikationen in Zusammenarbeit mit Forschern von Instituto de Química Médica (17)
2015
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Novel tacrine-grafted ugi adducts as multipotent anti-alzheimer drugs: A synthetic renewal in tacrine-ferulic acid hybrids
ChemMedChem, Vol. 10, Núm. 3, pp. 523-539
2014
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ITH12410/SC058: A new neuroprotective compound with potential in the treatment of Alzheimer's disease
ACS Chemical Neuroscience, Vol. 5, Núm. 9, pp. 770-775
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N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor
Journal of Medicinal Chemistry, Vol. 57, Núm. 24, pp. 10455-10463
2013
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Multipotent, permeable drug ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro
Current Alzheimer Research, Vol. 10, Núm. 8, pp. 797-808
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PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice
ACS Chemical Neuroscience, Vol. 4, Núm. 9, pp. 1267-1277
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Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: New dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease
European Journal of Medicinal Chemistry, Vol. 67, pp. 64-74
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Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: Effect against amyloid-β-induced neurotoxicity
ACS Chemical Neuroscience, Vol. 4, Núm. 4, pp. 547-565
2012
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Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling
European Journal of Medicinal Chemistry, Vol. 57, pp. 296-301
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Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease
European Journal of Medicinal Chemistry, Vol. 54, pp. 750-763
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α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: Synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties
Journal of Medicinal Chemistry, Vol. 55, Núm. 1, pp. 153-168
2011
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N-Acylaminophenothiazines: Neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease
European Journal of Medicinal Chemistry, Vol. 46, Núm. 6, pp. 2224-2235
2009
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Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease
Journal of Medicinal Chemistry, Vol. 52, Núm. 9, pp. 2724-2732
2004
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Naturally occurring cyclohexane epoxides: Sources, biological activities and synthesis
Chemical Reviews, Vol. 104, Núm. 6, pp. 2857-2899
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One or more =CH, =CC, and/or C=C bond(s) formed by rearrangement
Comprehensive Organic Functional Group Transformations II (Elsevier Ltd.), pp. 797-888
2003
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Naturally occurring diazo compounds: The kinamycins
Current Organic Chemistry, Vol. 7, Núm. 14, pp. 1433-1442
1999
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1,3-Dipolar cycloaddition of 3-azido-3-deoxy-1,2:5,6-di-O- isopropylidene-α-D-glucofuranose and C60
Journal of Chemical Research - Part S, pp. 680-681
1994
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5,6-Dihydro-1H, 4H-pyrazolo[4,3-f]pyrrolo[1,2-a][1,4]diazepines. Synthesis and pharmacological evaluation
European Journal of Medicinal Chemistry, Vol. 29, Núm. 3, pp. 233-239