Publicaciones en colaboración con investigadores/as de Universidad Central de Las Villas (17)

2018

  1. Antichagasic, Leishmanicidal, and Trichomonacidal Activity of 2-Benzyl-5-nitroindazole-Derived Amines

    ChemMedChem, Vol. 13, Núm. 12, pp. 1246-1259

  2. Drug repositioning for novel antitrichomonas from known antiprotozoan drugs using hierarchical screening

    Future Medicinal Chemistry, Vol. 10, Núm. 8, pp. 863-878

2015

  1. Synthesis and in vitro and in vivo biological evaluation of substituted nitroquinoxalin-2-ones and 2,3-diones as novel trichomonacidal agents

    European Journal of Medicinal Chemistry, Vol. 94, pp. 276-283

2014

  1. A sequential procedure for rapid and accurate identification of putative trichomonacidal agents

    Journal of Microbiological Methods, Vol. 105, pp. 162-167

  2. Antiprotozoan lead discovery by aligning dry and wet screening: Prediction, synthesis, and biological assay of novel quinoxalinones

    Bioorganic and Medicinal Chemistry, Vol. 22, Núm. 5, pp. 1568-1585

2012

  1. A fluorometric method for evaluation of pharmacological activity against intracellular Leishmania amastigotes

    Journal of Microbiological Methods, Vol. 89, Núm. 1, pp. 8-11

  2. Validation of a modified fluorimetric assay for the screening of trichomonacidal drugs

    Memorias do Instituto Oswaldo Cruz, Vol. 107, Núm. 5, pp. 637-643

2010

  1. QSAR for RNases and theoretic-experimental study of molecular diversity on peptide mass fingerprints of a new Leishmania infantum protein

    Molecular Diversity, Vol. 14, Núm. 2, pp. 349-369

2009

  1. Discovery of novel trichomonacidals using LDA-driven QSAR models and bond-based bilinear indices as molecular descriptors

    QSAR and Combinatorial Science, Vol. 28, Núm. 1, pp. 9-26

2008

  1. Bond-based linear indices in QSAR: Computational discovery of novel anti-trichomonal compounds

    Journal of Computer-Aided Molecular Design, Vol. 22, Núm. 8, pp. 523-540

  2. HP-Lattice QSAR for dynein proteins: Experimental proteomics (2D-electrophoresis, mass spectrometry) and theoretic study of a Leishmania infantum sequence

    Bioorganic and Medicinal Chemistry, Vol. 16, Núm. 16, pp. 7770-7776

  3. New antitrichomonal drug-like chemicals selected by bond (edge)-based TOMOCOMD-CARDD descriptors

    Journal of Biomolecular Screening, Vol. 13, Núm. 8, pp. 785-794

2006

  1. New ligand-based approach for the discovery of antitrypanosomal compounds

    Bioorganic and Medicinal Chemistry Letters, Vol. 16, Núm. 7, pp. 1898-1904

  2. Non-stochastic quadratic fingerprints and LDA-based QSAR models in hit and lead generation through virtual screening: theoretical and experimental assessment of a promising method for the discovery of new antimalarial compounds

    European Journal of Medicinal Chemistry, Vol. 41, Núm. 4, pp. 483-493

  3. Predicting antitrichomonal activity: A computational screening using atom-based bilinear indices and experimental proofs

    Bioorganic and Medicinal Chemistry, Vol. 14, Núm. 19, pp. 6502-6524

2005

  1. A computer-based approach to the rational discovery of new trichomonacidal drugs by atom-type linear indices

    Current Drug Discovery Technologies, Vol. 2, Núm. 4, pp. 245-265

  2. A linear discrimination analysis based virtual screening of trichomonacidal lead-like compounds: Outcomes of in silico studies supported by experimental results

    Bioorganic and Medicinal Chemistry Letters, Vol. 15, Núm. 17, pp. 3838-3843