Evaluación, control y bioseguridad de la toxicidad de agentes terapéuticos, ambientales y alimentarios
ECOBIOTOX
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Hospital Universitario de la Princesa
Madrid, EspañaPublicacions en col·laboració amb investigadors/es de Hospital Universitario de la Princesa (35)
2023
2022
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Synthesis and Pharmacological Evaluation of New N-Sulfonylureas as NLRP3 Inflammasome Inhibitors: Identification of a Hit Compound to Treat Gout
Journal of Medicinal Chemistry, Vol. 65, Núm. 8, pp. 6250-6260
2021
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In Silico Prediction of the Toxic Potential of Neuroprotective Bifunctional Molecules Based on Chiral N-Propargyl-1,2-amino Alcohol Derivatives
Chemical Research in Toxicology, Vol. 34, Núm. 5, pp. 1245-1249
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The coronavirus disease 2019 (Covid-19): Key emphasis on melatonin safety and therapeutic efficacy
Antioxidants, Vol. 10, Núm. 7
2020
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In Vitro and in Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases
ACS Chemical Neuroscience, Vol. 11, Núm. 22, pp. 3793-3801
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Melatonin benefits in oral cancer
Melatonin: Production, Functions and Benefits (Nova Science Publishers, Inc.), pp. 297-312
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Melatonin's efficacy in stroke patients; a matter of dose? A systematic review
Toxicology and Applied Pharmacology, Vol. 392
2019
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Potential of melatonin as adjuvant therapy of oral cancer in the era of epigenomics
Cancers, Vol. 11, Núm. 11
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Quinoxalinetacrine QT78, a cholinesterase inhibitor as a potential ligand for Alzheimer’s disease therapy
Molecules, Vol. 24, Núm. 8
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The emergence of melatonin in oncology: Focus on colorectal cancer
Medicinal Research Reviews, Vol. 39, Núm. 6, pp. 2239-2285
2018
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Analysis of gene expression profiles of CR80, a neuroprotective 1,8-Naphthyridine
Future Medicinal Chemistry, Vol. 10, Núm. 11, pp. 1289-1300
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How melatonin combats ischemic brain injury
Melatonin: Medical Uses and Role in Health and Disease (Nova Science Publishers, Inc.), pp. 185-209
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Melatonin and oral disorders: Potential therapeutic applications
Melatonin: Medical Uses and Role in Health and Disease (Nova Science Publishers, Inc.), pp. 295-310
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Modulation of serine/threonine phosphatases by melatonin: therapeutic approaches in neurodegenerative diseases
British Journal of Pharmacology, Vol. 175, Núm. 16, pp. 3220-3229
2017
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Ischemic brain injury: New insights on the protective role of melatonin
Free Radical Biology and Medicine, Vol. 104, pp. 32-53
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Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration
Future Medicinal Chemistry, Vol. 9, Núm. 8, pp. 765-780
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Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases
Angewandte Chemie - International Edition, Vol. 56, Núm. 41, pp. 12765-12769
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Neuroprotective effects of E-PodoFavalin-15999 (Atremorine®)
CNS Neuroscience and Therapeutics
2016
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Melatonin protects against oxygen and glucose deprivation by decreasing extracellular glutamate and Nox-derived ROS in rat hippocampal slices
NeuroToxicology, Vol. 57, pp. 61-68
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The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators
Journal of Medicinal Chemistry, Vol. 59, Núm. 21, pp. 9967-9973