Evaluación, control y bioseguridad de la toxicidad de agentes terapéuticos, ambientales y alimentarios
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Instituto de Química Médica
Madrid, EspañaPublikationen in Zusammenarbeit mit Forschern von Instituto de Química Médica (11)
2019
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New flavonoid–N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 34, Núm. 1, pp. 712-727
2018
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Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease
European Journal of Medicinal Chemistry, Vol. 156, pp. 534-553
2016
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New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties
European Journal of Medicinal Chemistry, Vol. 121, pp. 376-386
2015
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Novel tacrine-grafted ugi adducts as multipotent anti-alzheimer drugs: A synthetic renewal in tacrine-ferulic acid hybrids
ChemMedChem, Vol. 10, Núm. 3, pp. 523-539
2014
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Dibenzo[1,4,5]thiadiazepine: A hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases
European Journal of Medicinal Chemistry, Vol. 81, pp. 350-358
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ITH12410/SC058: A new neuroprotective compound with potential in the treatment of Alzheimer's disease
ACS Chemical Neuroscience, Vol. 5, Núm. 9, pp. 770-775
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New melatonin- N, N -dibenzyl(N -methyl)amine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for alzheimers disease
Journal of Medicinal Chemistry, Vol. 57, Núm. 9, pp. 3773-3785
2013
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Novel multitarget ligand ITH33/IQM9.21 provides neuroprotection in in vitro and in vivo models related to brain ischemia
Neuropharmacology, Vol. 67, pp. 403-411
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PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice
ACS Chemical Neuroscience, Vol. 4, Núm. 9, pp. 1267-1277
2012
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Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease
European Journal of Medicinal Chemistry, Vol. 54, pp. 750-763
2011
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N-Acylaminophenothiazines: Neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease
European Journal of Medicinal Chemistry, Vol. 46, Núm. 6, pp. 2224-2235