JOSÉ GREGORIO
GAVILANES FRANCO
Investigador hasta 2022
LUCÍA
GARCÍA ORTEGA
Profesora titular de universidad
Publicaciones en las que colabora con LUCÍA GARCÍA ORTEGA (29)
2020
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The ribotoxin α-sarcin can cleave the sarcin/ricin loop on late 60S pre-ribosomes
Nucleic acids research, Vol. 48, Núm. 11, pp. 6210-6222
2017
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Characterization of a new toxin from the entomopathogenic fungus Metarhizium anisopliae: The ribotoxin anisoplin
Biological Chemistry, Vol. 398, Núm. 1, pp. 135-142
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Fungal ribotoxins: A review of potential biotechnological applications
Toxins, Vol. 9, Núm. 2
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Minimized natural versions of fungal ribotoxins show improved active site plasticity
Archives of Biochemistry and Biophysics, Vol. 619, pp. 45-53
2016
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Involvement of loop 5 lysine residues and the N-terminal β-hairpin of the ribotoxin hirsutellin A on its insecticidal activity
Biological Chemistry, Vol. 397, Núm. 2, pp. 135-145
2015
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Involvement of loops 2 and 3 of α-sarcin on its ribotoxic activity
Toxicon, Vol. 96, pp. 1-9
2014
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Fungal ribotoxins: Natural protein-based weapons against insects
Toxicon, Vol. 83, pp. 69-74
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The acidic ribosomal stalk proteins are not required for the highly specific inactivation exerted by α-sarcin of the eukaryotic ribosome
Biochemistry, Vol. 53, Núm. 10, pp. 1545-1547
2013
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Fungal extracellular ribotoxins as insecticidal agents
Insect Biochemistry and Molecular Biology, Vol. 43, Núm. 1, pp. 39-46
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Hirsutellin A: A paradigmatic example of the insecticidal function of fungal ribotoxins
Insects, Vol. 4, Núm. 3, pp. 339-356
2012
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A non-cytotoxic but ribonucleolytically specific ribotoxin variant: Implication of tryptophan residues in the cytotoxicity of hirsutellin A
Biological Chemistry, Vol. 393, Núm. 6, pp. 449-456
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Implication of an Asp residue in the ribonucleolytic activity of hirsutellin A reveals new electrostatic interactions at the active site of ribotoxins
Biochimie, Vol. 94, Núm. 2, pp. 427-433
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Production and characterization of a colon cancer-specific immunotoxin based on the fungal ribotoxin α-sarcin
Protein Engineering, Design and Selection, Vol. 25, Núm. 8, pp. 425-435
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Production and characterization of scFvA33T1, an immunoRNase targeting colon cancer cells
FEBS Journal, Vol. 279, Núm. 17, pp. 3022-3032
2011
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The behavior of sea anemone actinoporins at the water-membrane interface
Biochimica et Biophysica Acta - Biomembranes, Vol. 1808, Núm. 9, pp. 2275-2288
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The ribonucleolytic activity of the ribotoxin α-sarcin is not essential for in vitro protein biosynthesis inhibition
Biochimica et Biophysica Acta - Proteins and Proteomics, Vol. 1814, Núm. 10, pp. 1377-1382
2010
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Cleavage of the sarcin-ricin loop of 23S rRNA differentially affects EF-G and EF-Tu binding
Nucleic Acids Research, Vol. 38, Núm. 12, pp. 4108-4119
2009
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Influence of key residues on the heterologous extracellular production of fungal ribonuclease U2 in the yeast Pichia pastoris
Protein Expression and Purification, Vol. 65, Núm. 2, pp. 223-229
2007
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Fungal ribotoxins: Molecular dissection of a family of natural killers
FEMS Microbiology Reviews, Vol. 31, Núm. 2, pp. 212-237
2006
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Tyr-48, a conserved residue in ribotoxins, is involved in the RNA-degrading activity of α-sarcin
Biological Chemistry, Vol. 387, Núm. 5, pp. 535-541