SILVIA
ORTEGA GUTIÉRREZ
Catedrática de universidad
MARÍA LUZ
LÓPEZ RODRÍGUEZ
Chercheuse jusqu' 2022
Publications dans lesquelles il/elle collabore avec MARÍA LUZ LÓPEZ RODRÍGUEZ (47)
2022
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New Trends in Aging Drug Discovery
Biomedicines, Vol. 10, Núm. 8
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Novel Antagonist of the Type 2 Lysophosphatidic Acid Receptor (LPA2), UCM-14216, Ameliorates Spinal Cord Injury in Mice
Journal of Medicinal Chemistry, Vol. 65, Núm. 16, pp. 10956-10974
2021
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Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson-Gilford Progeria Syndrome
ACS Central Science, Vol. 7, Núm. 8, pp. 1300-1310
2020
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A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration
Journal of Medicinal Chemistry, Vol. 63, Núm. 5, pp. 2372-2390
2019
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A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia
Journal of Medicinal Chemistry, Vol. 62, Núm. 13, pp. 6035-6046
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Blocking Ras inhibition as an antitumor strategy
Seminars in Cancer Biology, Vol. 54, pp. 91-100
2018
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Development of a Fluorescent Bodipy Probe for Visualization of the Serotonin 5-HT
1A
Receptor in Native Cells of the Immune System
Bioconjugate Chemistry, Vol. 29, Núm. 6, pp. 2021-2027
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2-AG limits Theiler's virus induced acute neuroinflammation by modulating microglia and promoting MDSCs
GLIA, Vol. 66, Núm. 7, pp. 1447-1463
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A Fluorescent Probe to Unravel Functional Features of Cannabinoid Receptor CB1 in Human Blood and Tonsil Immune System Cells
Bioconjugate Chemistry, Vol. 29, Núm. 2, pp. 382-389
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Monoacylglycerol lipase (MAGL) as a promising therapeutic target
Biochemical Pharmacology, Vol. 157, pp. 18-32
2017
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2-arachidonoylglycerol reduces proteoglycans and enhances remyelination in a progressive model of demyelination
Journal of Neuroscience, Vol. 37, Núm. 35, pp. 8385-8398
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Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling
Chemistry - A European Journal, Vol. 23, Núm. 7, pp. 1676-1685
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Ligand chain length drives activation of lipid G protein-coupled receptors
Scientific Reports, Vol. 7, Núm. 1
2016
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Chemoproteomic approach to explore the target profile of GPCR ligands: Application to 5-HT1A and 5-HT6 receptors
Chemistry - A European Journal, Vol. 22, Núm. 4, pp. 1313-1321
2015
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New inhibitors of angiogenesis with antitumor activity in vivo
Journal of Medicinal Chemistry, Vol. 58, Núm. 9, pp. 3757-3766
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The status of the lysophosphatidic acid receptor type 1 (LPA<inf>1</inf>R)
MedChemComm, Vol. 6, Núm. 1, pp. 13-23
2014
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A reversible and selective inhibitor of monoacylglycerol lipase ameliorates multiple sclerosis
Angewandte Chemie - International Edition, Vol. 53, Núm. 50, pp. 13765-13770
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The expression of cannabinoid receptor 1 is significantly increased in atopic patients
Journal of Allergy and Clinical Immunology, Vol. 133, Núm. 3
2012
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Mitochondrial CB
1
receptors regulate neuronal energy metabolism
Nature Neuroscience, Vol. 15, Núm. 4, pp. 558-564
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Chemical probes for the recognition of cannabinoid receptors in native systems
Angewandte Chemie - International Edition, Vol. 51, Núm. 28, pp. 6896-6899