Publicaciones en las que colabora con Leonardo Pardo Carrasco (19)

2017

  1. A new serotonin 5-HT 6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding

    Scientific Reports, Vol. 7

2014

  1. Serotonin 5-HT6receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease

    Journal of Medicinal Chemistry, Vol. 57, Núm. 17, pp. 7160-7181

  2. The extracellular entrance provides selectivity to serotonin 5-HT 7 receptor antagonists with antidepressant-like behavior in vivo

    Journal of Medicinal Chemistry, Vol. 57, Núm. 15, pp. 6879-6884

2011

  1. Development of non-peptide ligands of growth factor receptor-bound protein 2-src homology 2 domain using molecular modeling and NMR spectroscopy

    Journal of Medicinal Chemistry, Vol. 54, Núm. 4, pp. 1096-1100

  2. New serotonin 5-HT 1A receptor agonists with neuroprotective effect against ischemic cell damage

    Journal of Medicinal Chemistry, Vol. 54, Núm. 23, pp. 7986-7999

  3. The importance of solvation in the design of ligands targeting membrane proteins

    MedChemComm, Vol. 2, Núm. 3, pp. 160-164

2010

  1. Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation

    Journal of Medicinal Chemistry, Vol. 53, Núm. 3, pp. 1357-1369

2009

  1. Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-ht7/5-ht1a receptor selectivity

    Journal of Medicinal Chemistry, Vol. 52, Núm. 8, pp. 2384-2392

2005

  1. A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists

    Journal of Medicinal Chemistry, Vol. 48, Núm. 13, pp. 4216-4219

  2. Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT1AR agonists with selectivity over α1- adrenoceptors

    Journal of Medicinal Chemistry, Vol. 48, Núm. 7, pp. 2548-2558

2004

  1. Serotonin 5-HT 7 receptor antagonists

    Current Medicinal Chemistry - Central Nervous System Agents, Vol. 4, Núm. 3, pp. 203-214

2003

  1. Optimization of the Pharmacophore Model for 5-HT 7 R Antagonism. Design and Synthesis of New Naphtholactam and Naphthosultam Derivatives

    Journal of Medicinal Chemistry, Vol. 46, Núm. 26, pp. 5638-5650

  2. Benzimidazole derivatives.4. The recognition of the voluminous substituent attached to the basic amino group of 5-HT4 receptor antagonists

    Journal of Computer-Aided Molecular Design, Vol. 17, Núm. 8, pp. 515-524

  3. Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2- a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist

    Bioorganic and Medicinal Chemistry Letters, Vol. 13, Núm. 8, pp. 1429-1432

2002

  1. Benzimidazole derivatives. 3. 3D-QSAR/CoMFA model and computational simulation for the recognition of 5-HT4 receptor antagonists

    Journal of Medicinal Chemistry, Vol. 45, Núm. 22, pp. 4806-4815

  2. Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine1a receptor ligands to explore the three-dimensional structure of the receptor

    Molecular Pharmacology, Vol. 62, Núm. 1, pp. 15-21

2001

  1. 3-D-QSAR/CoMFA and recognition models of benzimidazole derivatives at the 5-HT(4) receptor

    Bioorganic and medicinal chemistry letters, Vol. 11, Núm. 21, pp. 2807-2811

  2. Computational model of the complex between GR113808 and the 5-HT4 receptor guided by site-directed mutagenesis and the crystal structure of rhodopsin

    Journal of Computer-Aided Molecular Design, Vol. 15, Núm. 11, pp. 1025-1033

  3. Study of the bioactive conformation of novel 5-HT4 receptor ligands: Influence of an intramolecular hydrogen bond

    Tetrahedron, Vol. 57, Núm. 31, pp. 6745-6749